Search Count: 7
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Discovery Of A Stable Macrocyclic O-Aminobenzamide Hsp90 Inhibitor Capable Of Significantly Decreasing Tumor Volume In A Mouse Xenograft Model.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.57 Å Release Date: 2011-07-13 Classification: CHAPERONE/CHAPERONE INHIBITOR Ligands: 06T |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-07-13
Ligands: 06T
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Discovery Of A Macrocyclic O-Aminobenzamide Hsp90 Inhibitor With Heterocyclic Tether That Shows Extended Biomarker Activity And In Vivo Efficacy In A Mouse Xenograft Model.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2011-06-08 Classification: CHAPERONE/CHAPERONE INHIBITOR Ligands: 06J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-06-08
Ligands: 06J
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Macrocyclic Lactams As Potent Hsp90 Inhibitors With Excellent Tumor Exposure And Extended Biomarker Activity.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2011-05-11 Classification: CHAPERONE/CHAPERONE INHIBITOR Ligands: 06H |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-05-11
Ligands: 06H
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Design And Sar Of Macrocyclic Hsp90 Inhibitors With Increased Metabolic Stability And Potent Cell-Proliferation Activity
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.57 Å Release Date: 2011-04-06 Classification: CHAPERONE/CHAPERONE INHIBITOR Ligands: 05S, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-04-06
Ligands: 05S, DMS
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Pdk-1 In Complex With The Inhibitor Compound-8I
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2010-02-16 Classification: TRANSFERASE Ligands: 8I1 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-02-16
Ligands: 8I1
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Pdk1 In Complex With Compound 8H
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2010-02-09 Classification: TRANSFERASE Ligands: 8H1, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-02-09
Ligands: 8H1, SO4
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Phosphoinositide-Dependent Protein Kinase 1 (Pdk-1) In Complex With Compound 9
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2009-08-25 Classification: TRANSFERASE Ligands: 9BD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2009-08-25
Ligands: 9BD