Search Count: 15
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Amg 193, A Clinical Stage Mta-Cooperative Prmt5 Inhibitor, Drives Anti-Tumor Activity Preclinically And In Patients With Mtap-Deleted Cancers
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.85 Å Release Date: 2024-10-02 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: GOL, DMS, A1ATH, MTA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-10-02
Ligands: GOL, DMS, A1ATH, MTA
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Identification Of An Imidazopyridine Scaffold To Generate Potent And Selective Tyk2 Inhibitors That Demonstrate Activity In An In Vivo Psoriasis Model
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.45 Å Release Date: 2017-09-06 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 9ZS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-09-06
Ligands: 9ZS
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Identification Of An Imidazopyridine Scaffold To Generate Potent And Selective Tyk2 Inhibitors That Demonstrate Activity In An In Vivo Psoriasis Model
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2017-09-06 Classification: Transferase/Transferase Inhibitor Ligands: 9ZS Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-09-06
Ligands: 9ZS
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Itk Kinase Domain In Complex With Compound 1 N-{1-[(1,1-Dioxo-1-Thian-2-Yl)(Phenyl)Methyl]-1H- Pyrazol-4-Yl}-5,5-Difluoro-5A-Methyl-1H,4H,4Ah,5H,5Ah,6H-Cyclopropa[F]Indazole-3-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2015-04-29 Classification: TRANSFERASE/INHIBITOR Ligands: 3P6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-04-29
Ligands: 3P6
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-4-Cyano-N-{2-[(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.31 Å Release Date: 2013-05-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0X6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: 0X6
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-N-[2-({[(1R,2R)-2-Fluorocyclopropyl]Carbonyl}Amino)Pyridin-4-Yl]Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2013-05-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0XH |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: 0XH
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-4-Cyano-N-[2-({[(1R,2R)-2-Fluorocyclopropyl]Carbonyl}Amino)Pyridin-4-Yl]Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2013-05-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0XP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: 0XP
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Jak2 Kinase (Jh1 Domain) In Complex With The Inhibitor Trans-4-[(8As)-2-[(1R)-1-Hydroxyethyl]Imidazo[4,5-D]Pyrrolo[2,3-B]Pyridin-1(8Ah)-Yl]Cyclohexanecarbonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.50 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1J5 Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 1J5
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Jak1 Kinase (Jh1 Domain) In Complex With The Inhibitor Trans-4-{2-[(1R)-1-Hydroxyethyl]Imidazo[4,5-D]Pyrrolo[2,3-B]Pyridin-1(6H)-Yl}Cyclohexanecarbonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1J5 Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 1J5
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Jak1 Kinase (Jh1 Domain) In Complex With The Inhibitor (Trans-4-{2-[(1R)-1-Hydroxyethyl]Imidazo[4,5-D]Pyrrolo[2,3-B]Pyridin-1(6H)-Yl}Cyclohexyl)Acetonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.35 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1J6 Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 1J6
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Jak1 Kinase (Jh1 Domain) In Complex With Compound 34
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.93 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 15T Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 15T
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The Jak1 Kinase Domain In Complex With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.17 Å Release Date: 2012-07-04 Classification: Transferase/Transferase Inhibitor Ligands: JAK, EDO Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-07-04
Ligands: JAK, EDO
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Jak1 Kinase (Jh1 Domain) In Complex With Compound 20
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.22 Å Release Date: 2012-07-04 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0Q2 Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-07-04
Ligands: 0Q2
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Discovery And Optimization Of C-2 Methyl Imidazo-Pyrrolopyridines As Potent And Orally Bioavailable Jak1 Inhibitors With Selectivity Over Jak2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.82 Å Release Date: 2012-07-04 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1RS Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-07-04
Ligands: 1RS
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Discovery And Optimization Of C-2 Methyl Imidazo-Pyrrolopyridines As Potent And Orally Bioavailable Jak1 Inhibitors With Selectivity Over Jak2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2012-07-04 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: JAK Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-07-04
Ligands: JAK