Search Count: 30
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Discovery Of Mta-Cooperative Prmt5 Inhibitors From Co-Factor Directed Dna-Encoded Library Screens
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.10 Å Release Date: 2025-05-07 Classification: TRANSFERASE/INHIBITOR Ligands: A1B6Y, MTA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-05-07
Ligands: A1B6Y, MTA
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From Dna-Encoded Library Screening To Am-9747 - An Mta-Cooperative Prmt5 Inhibitor With Potent Oral In Vivo Efficacy
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.25 Å Release Date: 2025-03-26 Classification: TRANSFERASE/INHIBITOR Ligands: A1BQW, MTA, GOL, PEG, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-03-26
Ligands: A1BQW, MTA, GOL, PEG, DMS
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Amg 193, A Clinical Stage Mta-Cooperative Prmt5 Inhibitor, Drives Anti-Tumor Activity Preclinically And In Patients With Mtap-Deleted Cancers
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.85 Å Release Date: 2024-10-02 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: GOL, DMS, A1ATH, MTA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-10-02
Ligands: GOL, DMS, A1ATH, MTA
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X-Ray Co-Crystal Structure Of Compound 7 With Mcl-1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2019-12-11 Classification: APOPTOSIS/INHIBITOR Ligands: Q57 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-11
Ligands: Q57
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X-Ray Co-Crystal Structure Of Compound 5 With Mcl-1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2019-12-11 Classification: APOPTOSIS/INHIBITOR Ligands: Q54 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-11
Ligands: Q54
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Co-Crystal Structure Of Compound 1 Bound To Human Mcl-1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2019-12-04 Classification: APOPTOSIS/INHIBITOR Ligands: Q4D |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q4D
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X-Ray Co-Crystal Structure Of Compound 20 With Mcl-1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.94 Å Release Date: 2019-12-04 Classification: APOPTOSIS/INHIBITOR Ligands: Q4S |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q4S
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X-Ray Co-Crystal Structure Of Compound 10 Bound To Human Mcl-1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.50 Å Release Date: 2019-12-04 Classification: APOPTOSIS/INHIBITOR Ligands: Q4V |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q4V
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X-Ray Co-Crystal Structure Of Compound 8 Bound To Human Mcl-1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.75 Å Release Date: 2019-12-04 Classification: APOPTOSIS/INHIBITOR Ligands: Q4Y |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q4Y
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X-Ray Co-Crystal Structure Of Compound 3 Bound To Human Mcl-1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.35 Å Release Date: 2019-12-04 Classification: APOPTOSIS/INHIBITOR Ligands: Q51 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q51
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Hmcl1 Inhibitor Complex
Organism: Homo sapiens
Method: SOLUTION NMR Release Date: 2019-05-22 Classification: APOPTOSIS/INHIBITOR Ligands: N8J |
Organism: Homo sapiens
Method: SOLUTION NMR
Release Date: 2019-05-22
Ligands: N8J
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Co-Crystal Structure Of Mcl1 With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2019-05-15 Classification: APOPTOSIS/INHIBITOR Ligands: LOD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-05-15
Ligands: LOD
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Co-Crystal Structure Of Mcl1 With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2019-05-15 Classification: APOPTOSIS/INHIBITOR Ligands: LOJ |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-05-15
Ligands: LOJ
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Co-Crystal Structure Of Mcl1 With Inhibitor 10
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2019-05-15 Classification: APOPTOSIS/INHIBITOR Ligands: N0J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-05-15
Ligands: N0J
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Crystal Structure Of Mcl1 With Inhibitor 8
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.48 Å Release Date: 2019-05-15 Classification: APOPTOSIS/INHIBITOR Ligands: N0M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-05-15
Ligands: N0M
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Crystal Structure Of Mcl1 With Inhibitor 7
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2019-05-15 Classification: APOPTOSIS Ligands: N0P |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-05-15
Ligands: N0P
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Crystal Structure Of Human Pi3K-Gamma In Complex With Amg511
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2012-08-29 Classification: Transferase/Inhibitor Ligands: SO4, 14K |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-08-29
Ligands: SO4, 14K
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Crystal Structure Of Human Pi3K-Gamma In Complex With A Pyridyl-Triazine-Sulfonamide Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.00 Å Release Date: 2012-08-08 Classification: Transferase/Inhibitor Ligands: SO4, F1S |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-08-08
Ligands: SO4, F1S
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Crystal Structure Of Human Pi3K-Gamma In Complex With A Pyridyl-Triazine Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.95 Å Release Date: 2012-05-16 Classification: Transferase/Inhibitor Ligands: SO4, 0KO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-05-16
Ligands: SO4, 0KO
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Crystal Structure Of Pi3K-Gamma In Complex With A Quinoline Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.55 Å Release Date: 2011-06-08 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: SO4, 2NQ |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-06-08
Ligands: SO4, 2NQ