Search Count: 32
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Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.27 Å Release Date: 2020-04-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, M1R |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22
Ligands: GDP, MG, M1R
 |
Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.03 Å Release Date: 2020-04-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, QH4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22
Ligands: GDP, MG, QH4
 |
Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.94 Å Release Date: 2020-04-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, M1X |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22
Ligands: GDP, MG, M1X
 |
Crystal Structure Phgdh In Complex With Nadh And 3-Phosphoglycerate At 1.77 A Resolution
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.77 Å Release Date: 2019-08-07 Classification: OXIDOREDUCTASE Ligands: 3PG, NAI |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-08-07
Ligands: 3PG, NAI
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Crystal Structure Of Phgdh In Complex With Compound 9
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.15 Å Release Date: 2019-08-07 Classification: OXIDOREDUCTASE Ligands: K4T, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-08-07
Ligands: K4T, SO4
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Crystal Structure Of Phgdh In Complex With Compound 40
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2019-08-07 Classification: OXIDOREDUCTASE Ligands: SO4, K52 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-08-07
Ligands: SO4, K52
 |
Crystal Structure Of Phgdh In Complex With Compound 15
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.42 Å Release Date: 2019-08-07 Classification: OXIDOREDUCTASE Ligands: SO4, K58 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-08-07
Ligands: SO4, K58
 |
Crystal Structure Of Phgdh In Complex With Compound 39
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2019-08-07 Classification: OXIDOREDUCTASE Ligands: SO4, K5N |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-08-07
Ligands: SO4, K5N
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Crystal Structure Of Phgdh In Complex With Bi-4924
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.98 Å Release Date: 2019-08-07 Classification: OXIDOREDUCTASE Ligands: K5K |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-08-07
Ligands: K5K
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Tetrahydropyridopyrimidines As Covalent Inhibitors Of Kras-G12C
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2018-12-12 Classification: ONCOPROTEIN Ligands: GDP, MG, K9M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2018-12-12
Ligands: GDP, MG, K9M
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Tetrahydropyridopyrimidines As Covalent Inhibitors Of Kras-G12C
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.72 Å Release Date: 2018-12-12 Classification: ONCOPROTEIN Ligands: GDP, MG, K9J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2018-12-12
Ligands: GDP, MG, K9J
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Crystal Structure Of Erk2 In Complex With Compound 22
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.76 Å Release Date: 2016-07-06 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 6QB, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-07-06
Ligands: 6QB, EDO
 |
Crystal Structure Of Cdk2 In Complex With Compound 22
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2016-07-06 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 6QB |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-07-06
Ligands: 6QB
 |
Crystal Structure Of Erk2 In Complex With An Inhibitor 14K
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.58 Å Release Date: 2015-09-16 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 41B |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-09-16
Ligands: 41B
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8-Tetrahydropyran-2-Yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (Bace1) Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-12-03 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 3J9 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-12-03
Ligands: NI, 3J9
 |
8-Tetrahydropyran-2-Yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (Bace1) Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-12-03 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 3UW |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-12-03
Ligands: NI, 3UW
 |
8-Tetrahydropyran-2-Yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (Bace1) Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-12-03 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 3UX |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-12-03
Ligands: NI, 3UX
 |
8-Tetrahydropyran-2-Yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (Bace1) Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-12-03 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 3UY |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-12-03
Ligands: NI, 3UY
 |
Discovery Of 5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine Inhibitors Of Erk2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2014-05-21 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 2SH |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-21
Ligands: 2SH
 |
Discovery Of 7-Thp Chromans: Bace1 Inhibitors That Reduce A-Beta In The Cns
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-05-14 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 2EX |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-14
Ligands: NI, 2EX