Search Count: 20
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Multi-Parameter Lead Optimization To Give An Oral Chk1 Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-Ylmethyl)Amino)-5-(Trifluoromethyl)Pyridin-2-Yl)Amino)Pyrazine-2-Carbonitrile (Cct245737)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.91 Å Release Date: 2016-05-25 Classification: TRANSFERASE Ligands: 5UY, EDO, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-05-25
Ligands: 5UY, EDO, GOL
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Crystal Structure Of Human Kdm4A In Complex With Compound 15
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.08 Å Release Date: 2016-01-20 Classification: OXIDOREDUCTASE Ligands: ZN, 5TZ, EDO, DMS, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, 5TZ, EDO, DMS, CL
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Crystal Structure Of Human Kdm4A In Complex With Compound 16
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2016-01-20 Classification: Oxidoreductase/Inhibitor Ligands: ZN, 5UP, EDO, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, 5UP, EDO, DMS
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Crystal Structure Of Human Kdm4A In Complex With Compound 40
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2016-01-20 Classification: OXIDOREDUCTASE Ligands: ZN, 5V7, DMS, EDO, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, 5V7, DMS, EDO, GOL
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Crystal Structure Of Human Kdm4A In Complex With Compound 58
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.22 Å Release Date: 2016-01-20 Classification: OXIDOREDUCTASE Ligands: ZN, N5J, EDO, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, N5J, EDO, DMS
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Crystal Structure Of Human Kdm4A In Complex With Compound 37
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.65 Å Release Date: 2016-01-20 Classification: OXIDOREDUCTASE Ligands: ZN, 5UB, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, 5UB, DMS
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Crystal Structure Of Human Kdm4A In Complex With Compound 52D
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.06 Å Release Date: 2016-01-20 Classification: OXIDOREDUCTASE Ligands: ZN, 5U8, DMS, GOL, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, 5U8, DMS, GOL, CL
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Crystal Structure Of Human Kdm4A In Complex With Compound 54A
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.16 Å Release Date: 2016-01-20 Classification: OXIDOREDUCTASE Ligands: ZN, 5UO, DMS, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, 5UO, DMS, GOL
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Crystal Structure Of Human Kdm4A In Complex With Compound 53A
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2016-01-20 Classification: OXIDOREDUCTASE Ligands: ZN, 5UL, DMS, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, 5UL, DMS, CL
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Crystal Structure Of Human Kdm4A In Complex With Compound 54J
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.24 Å Release Date: 2016-01-20 Classification: OXIDOREDUCTASE Ligands: ZN, 5UJ, DMS, GOL, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, 5UJ, DMS, GOL, CL
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Crystal Structure Of Human Jarid1B In Complex With Cct363901
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.35 Å Release Date: 2016-01-20 Classification: OXIDOREDUCTASE Ligands: ZN, MN, QAY, EDO, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-20
Ligands: ZN, MN, QAY, EDO, DMS
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Crystal Structure Of Human Jmjd2D Complexed With Kdopp7
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.88 Å Release Date: 2015-12-30 Classification: OXIDOREDUCTASE Ligands: ZN, NI, EDO, SO4, 5V3 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-12-30
Ligands: ZN, NI, EDO, SO4, 5V3
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Crystal Structure Of Human Jmjd2A Complexed With Kdooa011340
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.63 Å Release Date: 2015-12-30 Classification: OXIDOREDUCTASE Ligands: NI, ZN, SO4, 5V1 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-12-30
Ligands: NI, ZN, SO4, 5V1
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Crystal Structure Of Human Jmjd2D Complexed With Kdoam16
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.41 Å Release Date: 2015-12-16 Classification: OXIDOREDUCTASE Ligands: ZN, NI, 5V0, EDO, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-12-16
Ligands: ZN, NI, 5V0, EDO, SO4
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Aurora A Kinase Bound To A Highly Selective Imidazopyridine Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2013-11-20 Classification: TRANSFERASE Ligands: FH3 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-11-20
Ligands: FH3
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Aurora A Kinase Bound To A Highly Selective Imidazopyridine Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.75 Å Release Date: 2013-11-20 Classification: TRANSFERASE Ligands: FH5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-11-20
Ligands: FH5
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Crystal Structure Of Human Chk2 In Complex With Adp
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.25 Å Release Date: 2006-06-28 Classification: TRANSFERASE Ligands: CL, MG, NO3, ADP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2006-06-28
Ligands: CL, MG, NO3, ADP
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Crystal Structure Of Human Chk2 In Complex With Debromohymenialdisine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.70 Å Release Date: 2006-06-28 Classification: TRANSFERASE Ligands: MG, NO3, DBQ |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2006-06-28
Ligands: MG, NO3, DBQ
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Structure Of A Hsp90 Inhibitor Bound To The N-Terminus Of Yeast Hsp90.
Organism: Saccharomyces cerevisiae
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2005-09-29 Classification: CHAPERONE Ligands: CT5 |
Organism: Saccharomyces cerevisiae
Method: X-RAY DIFFRACTION
Release Date: 2005-09-29
Ligands: CT5
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Structure Of A Hsp90 Inhibitor Bound To The N-Terminus Of Yeast Hsp90.
Organism: Saccharomyces cerevisiae
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2005-09-29 Classification: CHAPERONE Ligands: KJ2 |
Organism: Saccharomyces cerevisiae
Method: X-RAY DIFFRACTION
Release Date: 2005-09-29
Ligands: KJ2