Search Count: 35
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Ba.2/Azd1061/Azd3152 Structure Analysis
Organism: Homo sapiens, Severe acute respiratory syndrome coronavirus 2
Method: X-RAY DIFFRACTION Resolution:3.30 Å Release Date: 2024-05-15 Classification: VIRAL PROTEIN/IMMUNE SYSTEM |
Organism: Homo sapiens, Severe acute respiratory syndrome coronavirus 2
Method: X-RAY DIFFRACTION
Release Date: 2024-05-15
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Identification Of An Imidazopyridine Scaffold To Generate Potent And Selective Tyk2 Inhibitors That Demonstrate Activity In An In Vivo Psoriasis Model
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.45 Å Release Date: 2017-09-06 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 9ZS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-09-06
Ligands: 9ZS
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Identification Of An Imidazopyridine Scaffold To Generate Potent And Selective Tyk2 Inhibitors That Demonstrate Activity In An In Vivo Psoriasis Model
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2017-09-06 Classification: Transferase/Transferase Inhibitor Ligands: 9ZS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-09-06
Ligands: 9ZS
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The Jak1 Kinase Domain In Complex With Compound 37
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.73 Å Release Date: 2013-10-02 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1Q3 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-10-02
Ligands: 1Q3
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Jak1 Kinase (Jh1 Domain) In Complex With Compound 6
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2013-10-02 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1Q4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-10-02
Ligands: 1Q4
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Tyk2 (Jh1) In Complex With Adenosine Di-Phosphate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.03 Å Release Date: 2013-08-14 Classification: HYDROLASE Ligands: ADP, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-08-14
Ligands: ADP, MG
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Jak2 Kinase (Jh1 Domain) In Complex With Tg101209
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2013-08-07 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1M3 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-08-07
Ligands: 1M3
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Jak2 Kinase (Jh1 Domain) In Complex With Compound 9
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2013-08-07 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1K3, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-08-07
Ligands: 1K3, GOL
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Jak2 Kinase (Jh1 Domain) With 2,6-Dichloro-N-(2-Oxo-2,5-Dihydropyridin-4-Yl)Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2013-06-19 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0X2 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-19
Ligands: 0X2
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Tyk2 Kinase (Jh1 Domain) With 2,6-Dichloro-N-(2-Oxo-2,5-Dihydropyridin-4-Yl)Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2013-06-19 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: SO4, EDO, GOL, 0X2 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-19
Ligands: SO4, EDO, GOL, 0X2
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2013-06-19 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0X5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-19
Ligands: 0X5
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Jak2 Kinase (Jh1 Domain) In Complex With 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2013-06-19 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0X5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-19
Ligands: 0X5
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-4-Cyano-N-{2-[(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.31 Å Release Date: 2013-05-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0X6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: 0X6
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-N-[2-({[(1R,2R)-2-Fluorocyclopropyl]Carbonyl}Amino)Pyridin-4-Yl]Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2013-05-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0XH |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: 0XH
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-4-Cyano-N-[2-({[(1R,2R)-2-Fluorocyclopropyl]Carbonyl}Amino)Pyridin-4-Yl]Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2013-05-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0XP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: 0XP
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The Jak1 Kinase Domain In Complex With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2013-05-22 Classification: TRANSFERASE Ligands: C5I, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: C5I, EDO
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Jak2 Kinase (Jh1 Domain) In Complex With The Inhibitor Trans-4-[(8As)-2-[(1R)-1-Hydroxyethyl]Imidazo[4,5-D]Pyrrolo[2,3-B]Pyridin-1(8Ah)-Yl]Cyclohexanecarbonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.50 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1J5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 1J5
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Jak1 Kinase (Jh1 Domain) In Complex With The Inhibitor Trans-4-{2-[(1R)-1-Hydroxyethyl]Imidazo[4,5-D]Pyrrolo[2,3-B]Pyridin-1(6H)-Yl}Cyclohexanecarbonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1J5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 1J5
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Jak1 Kinase (Jh1 Domain) In Complex With The Inhibitor (Trans-4-{2-[(1R)-1-Hydroxyethyl]Imidazo[4,5-D]Pyrrolo[2,3-B]Pyridin-1(6H)-Yl}Cyclohexyl)Acetonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.35 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 1J6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 1J6
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Jak1 Kinase (Jh1 Domain) In Complex With Compound 34
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.93 Å Release Date: 2013-05-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 15T |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-22
Ligands: 15T