Search Count: 15
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Discovery And Structure-Based Optimization Of Potent And Selective Wdr5 Inhibitors Containing A Dihydroisoquinolinone Bicyclic Core
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2020-01-01 Classification: TRANSCRIPTION Ligands: Q41 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-01-01
Ligands: Q41
 |
Wd Repeat-Containing Protein 5 Complexed With N-[(3,5-Dimethoxyphenyl)Methyl]-4'-Fluoro-5-{[(2E)-2-Imino-3-Methyl-2,3-Dihydro-1H-Imidazol-1-Yl]Methyl}-2'-Methyl[1,1'-Biphenyl]-3-Carboxamide (Compound 13)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.02 Å Release Date: 2020-01-01 Classification: GENE REGULATION/INHIBITOR Ligands: Q6S |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-01-01
Ligands: Q6S
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Discovery And Optimization Of Salicyclic Acid-Derived Sulfonamide Inhibitors Of The Wdr5:Myc Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2019-12-04 Classification: TRANSCRIPTION Ligands: Q0S |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q0S
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Discovery And Optimization Of Salicyclic Acid-Derived Sulfonamide Inhibitors Of The Wdr5:Myc Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.53 Å Release Date: 2019-12-04 Classification: TRANSCRIPTION Ligands: Q0M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q0M
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Discovery And Optimization Of Salicyclic Acid-Derived Sulfonamide Inhibitors Of The Wdr5:Myc Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.20 Å Release Date: 2019-12-04 Classification: TRANSCRIPTION/INHIBITOR Ligands: Q0Y |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q0Y
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Discovery And Optimization Of Salicyclic Acid-Derived Sulfonamide Inhibitors Of The Wdr5:Myc Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.55 Å Release Date: 2019-12-04 Classification: TRANSCRIPTION Ligands: Q1J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q1J
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Discovery And Optimization Of Salicyclic Acid-Derived Sulfonamide Inhibitors Of The Wdr5:Myc Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.26 Å Release Date: 2019-12-04 Classification: TRANSCRIPTION Ligands: Q1M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q1M
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Discovery And Optimization Of Salicyclic Acid-Derived Sulfonamide Inhibitors Of The Wdr5:Myc Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.57 Å Release Date: 2019-12-04 Classification: TRANSCRIPTION Ligands: Q1P, Q1S |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q1P, Q1S
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Discovery And Optimization Of Salicyclic Acid-Derived Sulfonamide Inhibitors Of The Wdr5:Myc Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2019-12-04 Classification: TRANSCRIPTION Ligands: Q1G |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-04
Ligands: Q1G
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Wdr5 In Complex With A Win Site Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2019-03-13 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: HH7, DMS, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-03-13
Ligands: HH7, DMS, SO4
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Wdr5 In Complex With A Win Site Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.56 Å Release Date: 2019-03-13 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: HHM, SO4, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-03-13
Ligands: HHM, SO4, DMS
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Discovery Of Potent 2-Aryl-6,7-Dihydro-5Hpyrrolo[ 1,2-A]Imidazoles As Wdr5 Win-Site Inhibitors Using Fragment-Based Methods And Structure-Based Design
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.22 Å Release Date: 2019-03-13 Classification: gene regulation/inhibitor Ligands: HLM |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-03-13
Ligands: HLM
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Displacement Of Wdr5 From Chromatin By A Pharmacological Win Site Inhibitor With Picomolar Affinity
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.10 Å Release Date: 2019-03-13 Classification: gene regulation/inhibitor Ligands: HLP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-03-13
Ligands: HLP
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Displacement Of Wdr5 From Chromatin By A Pharmacological Win Site Inhibitor With Picomolar Affinity
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2019-03-13 Classification: gene regulation/inhibitor Ligands: HLS, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-03-13
Ligands: HLS, SO4
 |
Displacement Of Wdr5 From Chromatin By A Pharmacological Win Site Inhibitor With Picomolar Affinity
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.66 Å Release Date: 2019-03-13 Classification: gene regulation/inhibitor Ligands: HLJ, EPE |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-03-13
Ligands: HLJ, EPE