| 61 |
IPD3987 |
The preclinical evaluation of a second-generation antivenom for treating snake envenoming in India |
Dr. Kartik Sunagar |
In this study, by employing chromatographic purification of the bulk, we have significantly enhanced the preclinical performance of the conventional Indian antivenom product. The effectiveness of the test batches of this ‘second-generation’ antivenom was evaluated using a variety of in vitro and in vivo preclinical assays, including venom recognition and...
In this study, by employing chromatographic purification of the bulk, we have significantly enhanced the preclinical performance of the conventional Indian antivenom product. The effectiveness of the test batches of this ‘second-generation’ antivenom was evaluated using a variety of in vitro and in vivo preclinical assays, including venom recognition and toxicity and pathology neutralisation. The outcomes of these experiments demonstrated the significantly superior performance of the purified product over all other major commercial Indian antivenoms.
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Evolutionary Venomics Lab, Center for Ecological Sciences, Indian Institute of Science, Bangalore, India |
Shotgun proteomics |
2024-11-24 |
35324665
|
| 62 |
IPD8910 |
A wolf in another wolf’s clothing: Post-genomic regulation dictates venom profiles of medically-important cryptic kraits in India |
Dr. Kartik Sunagar |
This study investigates the widespread cryptic Bungarus caeruleus (Comman krait) in India and clinical repercussions of their bits by implementing multidisciplinary approach involving proteomics, transcripomics, and assessment of toxicity and efficacy of currently marketed anivenoms. The study also aims at understanding the evolutionary relationships between these phenotypically simillar kraits.
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Evolutionary Venomics Lab, Center for Ecological Sciences, Indian Institute of Science, Bangalore, India |
Shotgun proteomics |
2024-11-24 |
33477742
|
| 63 |
IPD6103 |
Interactome identification of Histones H3 and H4 in the presence and absence of methyl methanesulfonate (MMS) in the pathogenic yeast Candida glabrata |
Dr. Rupinder Kaur |
The main goal of this project is to identify proteins in Candida glabrata that interact with histones H3 (CgHht) and H4 (CgHhf) under normal and MMS-treatment conditions.
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Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics (CDFD) |
Shotgun proteomics |
2024-12-07 |
32134928
|
| 64 |
IPD3310 |
Secretome analysis of Candida glabrata aspartyl protease-deficient strains |
Dr Rupinder Kaur |
The project is aimed at characterizing the effect of deletion of surface associated aspartyl protease(s) on the secretome of of the human opportunistic fungal pathogen Candida glabrata.
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Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics (CDFD) |
Shotgun proteomics |
2024-12-07 |
31621333
|
| 65 |
IPD2535 |
Label-free quantitative total membrane proteome analysis of Candida glabrata wild-type and eleven CgYapsins-deficient strain Cgyps1-11∆. |
Dr Rupinder Kaur |
The project is aimed at characterizing the effect of loss of a family of eleven aspartyl proteases (Cg Yapsins) on the abundance of proteins in the total membrane factions of Candida glabrata.
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Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics (CDFD) |
Shotgun proteomics |
2024-12-07 |
35051415
|
| 66 |
IPD8104 |
Secretome analysis of Candida glabrata wild-type and aspartyl protease-deficient strains |
Dr Rupinder Kaur |
The project is aimed at characterizing the secretome of a human opportunistic fungal pathogen Candida glabrata. Additionally, the effect of loss of a family of eleven aspartyl proteases (Cg Yapsins) on the Candida glabrata secretome is studied.
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Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics (CDFD) |
Shotgun proteomics |
2024-12-07 |
31621333
|
| 67 |
IPD1627 |
Identification of phosphorylated amino acids in CgSub2 protein in Candida glabrata |
Dr Rupinder Kaur |
The objective of the project is to identify the phosphorylated amino acid residues in CgSub2 in the pathogenic yeast Candida glabrata. For this analysis, wild-type cells and mutants lacking CgHog1 MAPK or CgSlt2MAPK or both CgHog1 and CgSlt2 MAPKs were used.
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Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics (CDFD) |
Bottom-up |
2024-12-07 |
|
| 68 |
IPD3061 |
Phosphatidylinositol 3-phosphate (PI3P) interactome analysis under varied iron conditions in Candida glabrata. |
Dr Rupinder Kaur |
The project is aimed at identifying proteins that interact with PI3P in low-iron, regular-iron and high-iron grown Candida glabrata cells.
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Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics (CDFD) |
Shotgun proteomics |
2024-12-07 |
37490387
|
| 69 |
IPD6532 |
Total membrane proteome analysis of Candida glabrata wild-type and eleven CgYapsins-deficient strain Cgyps1-11∆. |
Dr Rupinder Kaur |
The project is aimed at characterizing the effect of loss of a family of eleven aspartyl proteases (Cg Yapsins) on the global membrane proteome of Candida glabrata.
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Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics (CDFD) |
Shotgun proteomics |
2024-12-07 |
35051415
|
| 70 |
IPD8281 |
Quantitative secretome profiling of Candida glabrata wild-type and aspartyl protease-deficient strains |
Dr Rupinder Kaur |
The project is aimed at deciphering the proteins, which are differentially abundant in the secretome of Candida glabrata wild-type and a mutant strain deleted for eleven cell surface-associated aspartyl-proteases (CgYapsins).
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Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics (CDFD) |
Shotgun proteomics |
2024-12-07 |
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