ISDA: 9YXY

Deposition Date 2025-10-27

Release Date 2026-03-18

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9YXY

Keywords:

DNA BINDING PROTEIN

Title:

Crystal structure of EEPD1 EEP domain dimer at pH 5.5

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Endonuclease/exonuclease/phos
Chain IDs:A, B
Chain Length:302
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

EDO

GOL

IMD

Primary Citation

EEPD1 evolved a unique DNA clamping dimer protecting reversed replication forks.

Shen, R, Sarker, A.H, Chen, Y, Liu, M, Roy, S, Arvai, A.S, Bacolla, A, Ahmed, Z, Katsonis, P, Hammel, M, Kuraoka, I, Tsai, M.S, Irie, C, Webb, L, Lichtarge, O, Tsai, C.L, Tsutakawa, S.E, Schlacher, K, Tainer, J.A.Show

Nucleic Acids Res. 54 ? ? (2026)

PMID: 41830330 DOI: 10.1093/nar/gkag188

Primary Citation of related structures

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