9YFU image
Deposition Date 2025-09-26
Release Date 2026-03-25
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9YFU
Keywords:
SIGNALING PROTEIN
Title:
Structure of GPR61 bound to inverse agonist compound 15
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.08 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9YFU validation report
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Fab24 BAK5 light chain
Chain IDs:D (auth: C)
Chain Length:264
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Fab24 BAK5 heavy chain
Chain IDs:B (auth: H)
Chain Length:226
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Hinge-binding nanobody
Chain IDs:C (auth: N)
Chain Length:135
Number of Molecules:1
Biological Source:Lama glama
Protein Blast
Polymer Type:polypeptide(L)
Molecule:G-protein coupled receptor 61
Gene (Uniprot):cybC, GPR61
Chain IDs:A (auth: R)
Chain Length:542
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BZJ8,P0ABE7 Pfam ID:PF00001
Ligand Molecules
A1CWB
Primary Citation
Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled Receptor.
J.Med.Chem. 69 7393 7404 (2026)
PMID: 41834467 DOI: 10.1021/acs.jmedchem.6c00081
Primary Citation of related structures
9YFU
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