ISDA: 9WU2

Deposition Date 2025-09-17

Release Date 2026-02-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9WU2

Keywords:

IMMUNE SYSTEM

Title:

Crystal structure of cZ22-Fab in complex with left-handed dC(GC)3 DNA

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens, Synthesium

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.35 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.17

Space Group:

P 31

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:cZ22-Fab heavy chain
Chain IDs:A, C, G, I, M, O
Chain Length:236
Number of Molecules:6
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:cZ22-Fab light chain
Chain IDs:B, D, H, J, N, P
Chain Length:214
Number of Molecules:6
Biological Source:Mus musculus

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*CP*GP*CP*GP*CP*GP*
Chain IDs:E, F, K, L, Q, R
Chain Length:7
Number of Molecules:6
Biological Source:Homo sapiens

Ligand Molecules

GOL

Primary Citation

Structural basis of B-to-Z DNA transition mediated by an anti-Z-DNA antibody.

Lee, C.C, Hsu, S.F, Chang, Y.W, Chen, Y.W, Ho, M.R, Sugiyama, H, Wang, W.C, Wang, A.H.Show

Nucleic Acids Res. 54 ? ? (2026)

PMID: 41761907 DOI: 10.1093/nar/gkag160

Primary Citation of related structures

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