ISDA: 9WGW

Deposition Date 2025-08-25

Release Date 2026-04-01

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9WGW

Keywords:

CELL CYCLE

Title:

Crystal structure of human Haspin with ATP-mimicking inhibitor LJ-4827

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.70 Å

R-Value Free:

0.23

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):HASPIN
Chain IDs:A
Chain Length:798
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8TF76 Pfam ID:PF12330

Ligand Molecules

A1MBI

Primary Citation

In Silico Discovery of 5'-Modified 7-Deoxy-7-ethynyl-4'-thioadenosine as a HASPIN Inhibitor and Its Synergistic Anticancer Effect with the PLK1 Inhibitor.

Kwon, E.J, Mashelkar, K.K, Seo, J, Shin, Y.Z, Sung, K, Jang, S.C, Cheon, S.W, Lee, H, Lee, H.W, Kim, G, Han, B.W, Lee, S.K, Jeong, L.S, Cha, H.J.Show

Acs Cent.Sci. 9 1140 1149 (2023)

PMID: 37396870 DOI: 10.1021/acscentsci.3c00332

Primary Citation of related structures

Feedback Form