ISDA: 9WA7

Deposition Date 2025-08-11

Release Date 2026-03-11

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9WA7

Keywords:

DNA BINDING PROTEIN

Title:

Crystal Structure of Human NFIX in Complex with TGGCA(N3)TGCCA Palindromic DNA

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.31 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 21 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nuclear factor 1 X-type
Gene (Uniprot):NFIX
Chain IDs:A
Chain Length:163
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q14938 Pfam ID:PF10524, PF03165

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*AP*GP*TP*TP*GP*GP*
Chain IDs:B
Chain Length:18
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*GP*AP*TP*GP*GP*CP*
Chain IDs:C
Chain Length:18
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

Mechanistic Insights Into NFIX-Mediated DNA Recognition and Transcriptional Regulation in Skeletal Muscle.

Zhu, C, Liu, S, Chen, X, Qin, C, Wang, Y, Xue, C, Li, L, Du, W, Chen, X, Li, X, Shen, J, Song, H.Show

Smart Med 5 e70027 e70027 (2026)

PMID: 41623611 DOI: 10.1002/smmd.70027

Primary Citation of related structures

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