9VO2 image
Deposition Date 2025-07-01
Release Date 2026-03-18
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9VO2
Keywords:
MEMBRANE PROTEIN/IMMUNE SYSTEM
Title:
Cryo-EM structure of the OXGR1(CA)-Gq complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.70 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9VO2 validation report
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:A
Chain Length:370
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:338
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873 Pfam ID:PF25391
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: G)
Chain Length:59
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768 Pfam ID:PF00631
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:2-oxoglutarate receptor 1
Gene (Uniprot):OXGR1
Chain IDs:D (auth: R)
Chain Length:337
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96P68 Pfam ID:PF00001
Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:E (auth: S)
Chain Length:285
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
NA
Primary Citation
Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema.
Cell ? ? ? (2026)
PMID: 41791372 DOI: 10.1016/j.cell.2026.01.036
Primary Citation of related structures
9VO2
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