9V5P image
Deposition Date 2025-05-26
Release Date 2026-04-08
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9V5P
Keywords:
TRANSFERASE
Title:
Human DNMT1 (aa 698-1616) in complex with hemimethylated dsDNA and inhibitor DMT207
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.85 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9V5P validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA (cytosine-5)-methyltransf
Gene (Uniprot):DNMT1
Chain IDs:A
Chain Length:919
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P26358 Pfam ID:PF01426, PF00145 EC:2.1.1.37
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*AP*CP*TP*TP*AP*(5C
Chain IDs:C (auth: B)
Chain Length:12
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*CP*CP*TP*TP*CP*CP*
Chain IDs:B (auth: E)
Chain Length:12
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
A1EQ2
SAH
ZN
Primary Citation
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating beta-Thalassemia.
Adv Sci 13 e13469 e13469 (2026)
PMID: 41347631 DOI: 10.1002/advs.202513469
Primary Citation of related structures
9V5P
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