9UPG image
Deposition Date 2025-04-28
Release Date 2025-09-24
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9UPG
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of human olfactory CNGA2/A4/B1 in CaM-bound closed state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.87 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9UPG validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cyclic nucleotide-gated chann
Gene (Uniprot):CNGA2
Chain IDs:A, C
Chain Length:664
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q16280 Pfam ID:PF00520, PF00027, PF16526
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cyclic nucleotide-gated chann
Gene (Uniprot):CNGB1
Chain IDs:D (auth: B)
Chain Length:1251
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q14028 Pfam ID:PF00027, PF00520
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cyclic nucleotide-gated chann
Gene (Uniprot):CNGA4
Chain IDs:B (auth: D)
Chain Length:575
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8IV77 Pfam ID:PF00520, PF00027, PF16526
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Calmodulin-1
Gene (Uniprot):CALM1
Chain IDs:E (auth: H)
Chain Length:149
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P0DP23 Pfam ID:PF13499
Ligand Molecules
CA
Primary Citation
Structural mechanisms of assembly, gating, and calmodulin modulation of human olfactory CNG channel.
Nat Commun 16 9380 9380 (2025)
PMID: 41131016 DOI: 10.1038/s41467-025-64436-5
Primary Citation of related structures
9UPG
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