ISDA: 9ULP

Deposition Date 2025-04-20

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9ULP

Keywords:

IMMUNE SYSTEM

Title:

Crystal structure of FtsB from Streptococcus pyogenes in complex with Nb1 nanobody

Biological Source:

Source Organism(s):

Streptococcus pyogenes (Taxon ID: 1314)
Vicugna pacos (Taxon ID: 30538)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.55 Å

R-Value Free:

0.30

R-Value Work:

0.25

R-Value Observed:

0.25

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Iron-hydroxamate ABC transpor
Gene (Uniprot):E0F66_02370
Chain IDs:A, C (auth: B)
Chain Length:283
Number of Molecules:2
Biological Source:Streptococcus pyogenes

UniProt ID:A0A5S4TPK8

Polymer Type:polypeptide(L)
Molecule:VHH
Chain IDs:B (auth: C), D
Chain Length:124
Number of Molecules:2
Biological Source:Vicugna pacos

Primary Citation

Development of an inhibitory monoclonal nanobody targeting Streptococcus pyogenes siderophore binding protein FtsB.

Fernandez-Perez, J, de Vega, S, Caaveiro, J.M.M, Nakakido, M, Nagatoishi, S, Senoo, A, Tanoi, K, Nozawa, T, Nakagawa, I, Tsumoto, K.Show

J.Biol.Chem. 302 111224 111224 (2026)

PMID: 41651419 DOI: 10.1016/j.jbc.2026.111224

Primary Citation of related structures

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