9T95 image
Deposition Date 2025-11-13
Release Date 2026-04-08
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9T95
Keywords:
LIGASE
Title:
Crystal structure of beta-TrCP bound by diphosphorylated NRF2 degron peptide.
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.15 Å
R-Value Free:
0.27
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 21 21 21
9T95 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:F-box/WD repeat-containing pr
Gene (Uniprot):BTRC
Mutagens:L188E, L192E
Chain IDs:A
Chain Length:365
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y297 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nuclear factor erythroid 2-re
Gene (Uniprot):NFE2L2
Chain IDs:B
Chain Length:12
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q16236
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP B SER modified residue
Primary Citation
Targeting the Interaction of NRF2 and beta-TrCP with Molecular Glues
Acs Chem.Biol. ? ? ? (2026)
DOI: 10.1021/acschembio.5c01006
Primary Citation of related structures
9T95
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