9SZP image
Deposition Date 2025-10-15
Release Date 2026-04-01
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9SZP
Keywords:
RNA BINDING PROTEIN
Title:
Crystal structure of the human YTHDC2 YTH domain in complex with m6A DNA
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
DNA molecule (Taxon ID: 2853804)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.58 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.20
Space Group:
C 2 2 21
9SZP validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:3'-5' RNA helicase YTHDC2
Gene (Uniprot):YTHDC2
Chain IDs:A
Chain Length:161
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H6S0 Pfam ID:PF04146
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*GP*GP*(6MA)P*CP*TP
Chain IDs:B
Chain Length:6
Number of Molecules:1
Biological Source:DNA molecule
Primary Citation
A DNA-Based Binding Assay for the m 6 A-RNA Reader Proteins.
Chembiochem 27 e202500897 e202500897 (2026)
PMID: 41863816 DOI: 10.1002/cbic.202500897
Primary Citation of related structures
9SZP
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