ISDA: 9RWZ

Deposition Date 2025-07-10

Release Date 2026-03-18

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9RWZ

Keywords:

LIGASE

Title:

ZSWIM8-CUL3 complex bound to AGO2-miR-7-CYRANO

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera aff. frugiperda 1 bold-2017, Escherichia coli, Spodoptera

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Protein argonaute-2
Chain IDs:A
Chain Length:870
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Elongin-B
Chain IDs:B, C
Chain Length:118
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Elongin-C
Chain IDs:D, E
Chain Length:112
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:miR-7
Chain IDs:F (auth: G)
Chain Length:24
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Cullin-3
Mutagens:I342R, L346D
Chain IDs:G (auth: H), H (auth: I)
Chain Length:396
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Zinc finger SWIM domain-conta
Chain IDs:J (auth: N), K (auth: M)
Chain Length:1866
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:CYRANO trigger RNA
Chain IDs:I (auth: T)
Chain Length:120
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation.

Farnung, J, Slobodyanyuk, E, Wang, P.Y, Blodgett, L.W, Lin, D.H, von Gronau, S, Schulman, B.A, Bartel, D.P.Show

Nature ? ? ? (2026)

PMID: 41851464 DOI: 10.1038/s41586-026-10232-0

Primary Citation of related structures

Feedback Form