9RAY image
Deposition Date 2025-05-21
Release Date 2026-04-01
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9RAY
Keywords:
LYASE
Title:
Crystal structure of human carbonic anhydrase I in complex with N-benzyl-2-(2-chloro-N-(3-chloro-4-methoxyphenyl)acetamido)-2-(4-sulfamoylphenyl)acetamide
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.31 Å
R-Value Free:
0.22
R-Value Work:
0.19
Space Group:
P 1 21 1
9RAY validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Carbonic anhydrase 2
Gene (Uniprot):CA2
Chain IDs:A (auth: AAA)
Chain Length:260
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P00918 Pfam ID:PF00194 EC:4.2.1.1
Ligand Molecules
A1JD1
ZN
Primary Citation
Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis-induced tumor cell death.
Eur.J.Med.Chem. 300 118107 118107 (2025)
PMID: 40929808 DOI: 10.1016/j.ejmech.2025.118107
Primary Citation of related structures
9RAY
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