9R19 image
Deposition Date 2025-04-25
Release Date 2025-09-17
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9R19
Keywords:
HYDROLASE
Title:
Crystal structure of human ACE2 in complex with VHH B07 and VHH B10
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Vicugna pacos (Taxon ID: 30538)
Expression System(s):
Homo sapiens, Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.69 Å
R-Value Free:
0.25
R-Value Work:
0.21
R-Value Observed:
0.22
Space Group:
P 1 21 1
9R19 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Processed angiotensin-convert
Gene (Uniprot):ACE2
Chain IDs:A, B, C
Chain Length:604
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q9BYF1 Pfam ID:PF01401 EC:3.4.15.1
Polymer Type:polypeptide(L)
Molecule:VHH B10
Chain IDs:D, E, F
Chain Length:153
Number of Molecules:3
Biological Source:Vicugna pacos
Polymer Type:polypeptide(L)
Molecule:VHH B07
Chain IDs:G, H, I
Chain Length:143
Number of Molecules:3
Biological Source:Vicugna pacos
Ligand Molecules
CL
NAG
Primary Citation
Targeting ACE2 with a camelid antibody inhibits SARS-CoV-2 binding and has protective effects in vivo.
Nat Commun 16 10268 10268 (2025)
PMID: 41271706 DOI: 10.1038/s41467-025-65144-w
Primary Citation of related structures
9R19
Feedback Form
Name
Email
Institute
Feedback