9QRN image
Deposition Date 2025-04-03
Release Date 2025-09-24
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9QRN
Keywords:
DNA BINDING PROTEIN
Title:
DNA polymerase without DNA or inhibitor
Biological Source:
Source Organism(s):
Enterococcus faecium (Taxon ID: 1352)
Escherichia coli (Taxon ID: 562)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.10 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9QRN validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA polymerase III PolC-type
Gene (Uniprot):polC
Mutagens:D431A, E433A
Chain IDs:A
Chain Length:1474
Number of Molecules:1
Biological Source:Enterococcus faecium
UniProt ID:A0A9X4B319 Pfam ID:PF14480, PF11490, PF01336, PF02811, PF00929, PF07733, PF17657, PF14579
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*TP*AP*A)-3')
Chain IDs:B (auth: E)
Chain Length:3
Number of Molecules:1
Biological Source:Escherichia coli
Ligand Molecules
MG
ZN
Primary Citation
A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens.
Nat Commun 16 9784 9784 (2025)
PMID: 41198680 DOI: 10.1038/s41467-025-65324-8
Primary Citation of related structures
9QPC
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