9QPC image
Deposition Date 2025-03-26
Release Date 2025-09-24
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9QPC
Title:
DNA polymerase with inhibitor
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.80 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:DNA polymerase III PolC-type
Mutagens:D431A, E433A
Chain IDs:A
Chain Length:1474
Number of Molecules:1
Biological Source:Enterococcus faecium
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*TP*AP*A)-3')
Chain IDs:B (auth: E)
Chain Length:3
Number of Molecules:1
Biological Source:Escherichia coli
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*TP*AP*GP*GP*TP*GP
Chain IDs:C (auth: P)
Chain Length:33
Number of Molecules:1
Biological Source:Escherichia coli
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*CP*CP*AP*TP*GP*CP
Chain IDs:D (auth: T)
Chain Length:42
Number of Molecules:1
Biological Source:Escherichia coli
Primary Citation
A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens.
Nat Commun 16 9784 9784 (2025)
PMID: 41198680 DOI: 10.1038/s41467-025-65324-8
Primary Citation of related structures
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