ISDA: 9PIZ

Deposition Date 2025-07-11

Release Date 2026-03-11

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9PIZ

Keywords:

ONCOPROTEIN

Title:

Structure of KRAS-G12C bound to 1-[(4aR,10P,13R)-10-[5-amino-4-fluoro-3-methyl-2-(trifluoromethyl)phenyl]-11-chloro-9-fluoro-1,2,4a,5-tetrahydropyrazino[1',2':4,5][1,4]oxazino[2,3-c]quinolin-3(4H)-yl]prop-2-en-1-one (compound 15)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli, Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.94 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12C
Chain IDs:A
Chain Length:171
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Polymer Type:polypeptide(L)
Molecule:anti-KRAS heavy chain
Chain IDs:B (auth: H)
Chain Length:226
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:anti-KRAS light chain
Chain IDs:C (auth: I)
Chain Length:215
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules