ISDA: 9P24

Deposition Date 2025-06-11

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9P24

Keywords:

MEMBRANE PROTEIN

Title:

Structure of human cardiac sodium channel Nav1.5 in intermediate open state

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.48 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sodium channel protein type 5
Gene (Uniprot):SCN5A
Chain IDs:A
Chain Length:2016
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q14524 Pfam ID:PF00520, PF11933, PF06512

Ligand Molecules

9Z9

NAG

Primary Citation

Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Na v 1.5.

Biswas, R, Lopez-Serrano, A.L, Purohit, A, Ramirez-Navarro, A, Huang, H.L, Cheng, X, Heissler, S.M, Deschenes, I, Chinthalapudi, K.Show

Nat Commun 17 ? ? (2026)

PMID: 41698958 DOI: 10.1038/s41467-026-69672-x

Primary Citation of related structures

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