9OVU image
Deposition Date 2025-05-31
Release Date 2026-04-08
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9OVU
Keywords:
MEMBRANE PROTEIN
Title:
Composite map of GluA1/A2 in the activated state, in complex with positive allosteric modulator (R,R)-2b and agonist glutamate (ATD-LBD-TMD)
Biological Source:
Source Organism(s):
Rattus norvegicus (Taxon ID: 10116)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OVU validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform Flip of Glutamate rec
Gene (Uniprot):Gria1
Chain IDs:A, C
Chain Length:835
Number of Molecules:2
Biological Source:Rattus norvegicus
UniProt ID:P19490 Pfam ID:PF01094, PF10613, PF00060
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform Flip of Glutamate rec
Gene (Uniprot):Gria2
Chain IDs:B, D
Chain Length:842
Number of Molecules:2
Biological Source:Rattus norvegicus
UniProt ID:P19491 Pfam ID:PF01094, PF10613, PF00060
Ligand Molecules
FWF
GLU
NA
Primary Citation
Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/A2 AMPA receptor core.
Nat Commun ? ? ? (2026)
PMID: 41904128 DOI: 10.1038/s41467-026-71063-1
Primary Citation of related structures
9OVU
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