ISDA: 9OHC

Deposition Date 2025-05-04

Release Date 2026-03-11

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9OHC

Keywords:

TOXIN

Title:

CryoEM structure of Toxin B (TcdB) from clostridioides difficile complexed with taurochenodeoxycholic acid (TCDCA)

Biological Source:

Source Organism(s):

Clostridioides difficile (Taxon ID: 1496)

Expression System(s):

Priestia megaterium

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.28 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Toxin B
Gene (Uniprot):tcdB
Chain IDs:A
Chain Length:2372
Number of Molecules:1
Biological Source:Clostridioides difficile

UniProt ID:P18177 EC:2.4.1.B62

Ligand Molecules

TUD

Primary Citation

Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin.

Miletic, S, Icho, S, Li, Z, Tam, J, Rose, E.C, Perkins, C.E, Nakhi, A, Yang, X, Hang, H.C, Rubinstein, J.L, Dosa, P.I, Theriot, C.M, Melnyk, R.A.Show

Nat Microbiol 10 3215 3228 (2025)

PMID: 41254394 DOI: 10.1038/s41564-025-02179-1

Primary Citation of related structures

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