ISDA: 9OBO

Deposition Date 2025-04-22

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9OBO

Keywords:

LYASE

Title:

Crystal structure of Mycobacterium tuberculosis isocitrate lyase 2 fixed in the apo form with disulfide bonds

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis CDC1551 (Taxon ID: 83331)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.60 Å

R-Value Free:

0.22

R-Value Work:

0.17

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isocitrate lyase 2
Gene (Uniprot):icl2
Mutagens:Q635C, V708C, V734C
Chain IDs:A, B, C, D
Chain Length:766
Number of Molecules:4
Biological Source:Mycobacterium tuberculosis CDC1551

UniProt ID:Q8VJU4 Pfam ID:PF00463

Ligand Molecules

EDO

SIN

Primary Citation

Structural basis of allosteric activation of Mycobacterium tuberculosis isocitrate lyase 2.

Huang, E.Y, Kwai, B.X.C, Jiao, W, Taka, J, Wilde, K.L, Sethi, A, Maher, M.J, Bashiri, G, Leung, I.K.H.Show

Commun Biol ? ? ? (2026)

PMID: 41803459 DOI: 10.1038/s42003-026-09821-6

Primary Citation of related structures

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