9NY9 image
Deposition Date 2025-03-27
Release Date 2026-04-08
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9NY9
Keywords:
TRANSFERASE/RNA
Title:
Crystal structure of the post-reactive state of porcine OAS1 in complex with dsRNA, catalytic center bound PPi, and dissociated 25A2.
Biological Source:
Source Organism(s):
Sus scrofa (Taxon ID: 9823)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.74 Å
R-Value Free:
0.25
R-Value Work:
0.23
Space Group:
P 43 21 2
9NY9 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:2'-5'-oligoadenylate synthase
Gene (Uniprot):OAS1
Chain IDs:A
Chain Length:357
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:Q29599 Pfam ID:PF01909, PF10421 EC:2.7.7.84
Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(*GP*GP*CP*UP*UP*UP*
Chain IDs:B
Chain Length:19
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(*UP*UP*CP*AP*UP*AP*
Chain IDs:C
Chain Length:19
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
25L
MG
POP
Primary Citation
The Enzymatic Mechanism of OAS: How Metal Ions and Quantum Effects Help Activate Innate Immunity
To Be Published ? ? ? (?)
Primary Citation of related structures
4RWN
4RWQ
4RWP
4RWO
9NXS
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