9MWI image
Deposition Date 2025-01-17
Release Date 2025-11-26
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9MWI
Keywords:
Title:
Structure of rat neuronal nitric oxide synthase R349A mutant heme domain bound with N-(3-(2-((3-(thiazole-5-carboximidamido)benzyl)amino)ethyl)phenyl)thiazole-5-carboximidamide
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.05 Å
R-Value Free:
0.27
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
C 2 2 21
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nitric oxide synthase, brain
Gene (Uniprot):Nos1
Mutagens:R349A
Chain IDs:A
Chain Length:422
Number of Molecules:1
Biological Source:Rattus norvegicus
Primary Citation
New Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma.
J.Med.Chem. 69 2310 2329 (2026)
PMID: 41615895 DOI: 10.1021/acs.jmedchem.5c02154
Primary Citation of related structures
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