ISDA: 9M1O

Deposition Date 2025-02-26

Release Date 2025-07-23

Last Version Date 2025-07-23

Entry Detail

PDB ID:

9M1O

Keywords:

MEMBRANE PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structures of NPFFR2 complex with neuropeptide FF

Biological Source:

Source Organism(s):

Escherichia coli (Taxon ID: 562)
Homo sapiens (Taxon ID: 9606)
Rattus norvegicus (Taxon ID: 10116)
Bos taurus (Taxon ID: 9913)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.49 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Mutagens:G203A,A326S
Chain IDs:F (auth: A)
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:B
Chain Length:366
Number of Molecules:1
Biological Source:Rattus norvegicus

UniProt ID:P54311 Pfam ID:PF00400, PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P63212 Pfam ID:PF00631

Polymer Type:polypeptide(L)
Molecule:Morphine-modulating neuropept
Chain IDs:D (auth: L)
Chain Length:9
Number of Molecules:1
Biological Source:synthetic construct

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Soluble cytochrome b562,Neuro
Gene (Uniprot):NPFFR2
Chain IDs:A (auth: R)
Chain Length:589
Number of Molecules:1
Biological Source:Escherichia coli, Homo sapiens

UniProt ID:Q9Y5X5 Pfam ID:PF00001

Polymer Type:polypeptide(L)
Molecule:scfv16
Chain IDs:E (auth: S)
Chain Length:247
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

Structural basis of peptide recognition and modulation for neuropeptide FF receptors

Li, X.Z, Zhang, H, Hu, W, Wu, K, Li, S, Jin, S.S, Yin, Y.L, Yuan, Q.N, Xu, H.E, Pan, B.X, Jiang, Y.Show

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Primary Citation of related structures

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