ISDA: 9L8L

Deposition Date 2024-12-27

Release Date 2025-12-31

Last Version Date 2025-12-31

Entry Detail

PDB ID:

9L8L

Keywords:

MEMBRANE PROTEIN

Title:

Structure of GPCR megacomplex bound to agonists

Biological Source:

Source Organism(s):

Bos taurus (Taxon ID: 9913)
Rattus norvegicus (Taxon ID: 10116)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli, Trichoplusia ni, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.22 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAS
Chain IDs:A
Chain Length:394
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P04896 Pfam ID:PF00503 EC:3.6.5.1

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:B
Chain Length:351
Number of Molecules:1
Biological Source:Rattus norvegicus

UniProt ID:P54311 Pfam ID:PF00400, PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-arrestin-1
Gene (Uniprot):ARRB1
Chain IDs:C
Chain Length:392
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P49407 Pfam ID:PF00339, PF02752

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D (auth: G)
Chain Length:68
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P63212 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-2 adrenergic receptor
Gene (Uniprot):ADRB2
Mutagens:K237R,G276S,I277V
Chain IDs:E (auth: R)
Chain Length:421
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P07550 Pfam ID:PF00001

Ligand Molecules