ISDA: 9KPG

Deposition Date 2024-11-22

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9KPG

Keywords:

SIGNALING PROTEIN

Title:

Crystal structure of human CASTOR2-arginine

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.85 Å

R-Value Free:

0.23

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Cytosolic arginine sensor for
Chain IDs:A, B (auth: C)
Chain Length:337
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

ARG

Primary Citation

CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity.

Liu, C, Zhang, Y, Wang, Y, Wu, M, Li, Y, Wei, J, Shi, J, Wang, R, Su, L, Yang, T, Li, J, Xiao, J, Ding, J, Zhang, T.Show

Mol.Cell 86 362 375.e4 (2026)

PMID: 41506264 DOI: 10.1016/j.molcel.2025.12.016

Primary Citation of related structures

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