ISDA: 9KP4

Deposition Date 2024-11-22

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9KP4

Keywords:

SIGNALING PROTEIN

Title:

Crystal structure of human CASTOR1 in apo form

Biological Source:

Source Organism(s):

Escherichia coli (strain K12) (Taxon ID: 83333)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.08 Å

R-Value Free:

0.26

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Maltose/maltodextrin-binding
Gene (Uniprot):malE, CASTOR1
Chain IDs:A, B, C, D
Chain Length:704
Number of Molecules:4
Biological Source:Escherichia coli (strain K12), Homo sapiens

UniProt ID:P0AEX9,Q8WTX7 Pfam ID:PF01547, PF18700, PF13840, PF21389 EC:7.5.2.1

Ligand Molecules

ACY

NH4

Peptide-like Molecules

PRD_900001

Primary Citation

CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity.

Liu, C, Zhang, Y, Wang, Y, Wu, M, Li, Y, Wei, J, Shi, J, Wang, R, Su, L, Yang, T, Li, J, Xiao, J, Ding, J, Zhang, T.Show

Mol.Cell 86 362 375.e4 (2026)

PMID: 41506264 DOI: 10.1016/j.molcel.2025.12.016

Primary Citation of related structures

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