ISDA: 9JI5

Deposition Date 2024-09-11

Release Date 2025-09-17

Last Version Date 2025-09-17

Entry Detail

PDB ID:

9JI5

Keywords:

GENE REGULATION

Title:

Cryo-EM structure of Mycobacterium tuberculosis transcription activation complex with six PhoP molecules

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis (Taxon ID: 1773)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Gene (Uniprot):rpoA
Chain IDs:A, B, O (auth: I)
Chain Length:347
Number of Molecules:3
Biological Source:Mycobacterium tuberculosis

UniProt ID:P9WGZ1 Pfam ID:PF01193, PF01000, PF03118 EC:2.7.7.6

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Gene (Uniprot):rpoB
Chain IDs:C
Chain Length:1178
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis

UniProt ID:P9WGY9 Pfam ID:PF04563, PF04561, PF04565, PF10385, PF00562, PF04560 EC:2.7.7.6

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Gene (Uniprot):rpoC
Chain IDs:D
Chain Length:1316
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis

UniProt ID:P9WGY7 Pfam ID:PF04997, PF00623, PF04983, PF05000, PF04998 EC:2.7.7.6

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Gene (Uniprot):rpoZ
Chain IDs:E
Chain Length:110
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis

UniProt ID:A0A045H2R3,P9WGY5 Pfam ID:PF01192

Protein Blast

Polymer Type:polypeptide(L)
Molecule:RNA polymerase sigma factor S
Gene (Uniprot):sigA
Chain IDs:H (auth: F)
Chain Length:528
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis

UniProt ID:A0A045HD00,P9WGI1 Pfam ID:PF00140, PF04542, PF04539, PF04545

Polymer Type:polydeoxyribonucleotide
Molecule:Template strand DNA
Chain IDs:G
Chain Length:108
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis

Polymer Type:polydeoxyribonucleotide
Molecule:Non-template strand DNA
Chain IDs:F (auth: H)
Chain Length:108
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-binding response regulato
Gene (Uniprot):phoP
Chain IDs:I (auth: J), J (auth: M), K (auth: O), L (auth: K), M (auth: L), N
Chain Length:247
Number of Molecules:6
Biological Source:Mycobacterium tuberculosis

UniProt ID:A0A045J469,P71814 Pfam ID:PF00072, PF00486

Ligand Molecules

Primary Citation

Cryo-EM structure of Mycobacterium tuberculosis transcription activation complex with six PhoP molecules

Lin, W, Feng, Y.Show

To be published ? ? ? (?)

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