ISDA: 9HR6

Deposition Date 2024-12-17

Release Date 2025-09-17

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9HR6

Keywords:

PROTEIN FIBRIL

Title:

cryoEM structure of amyloid fibrils formed by human RIPK1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.57 Å

Aggregation State:

HELICAL ARRAY

Reconstruction Method:

HELICAL

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Receptor-interacting serine/t
Gene (Uniprot):RIPK1
Chain IDs:A, B, C, D, E
Chain Length:88
Number of Molecules:5
Biological Source:Homo sapiens

UniProt ID:Q13546 EC:2.7.10.2

Ligand Molecules

Primary Citation

Structural basis for amyloid fibril assembly by the master cell-signaling regulator receptor-interacting protein kinase 1.

Polonio, P, Lopez-Alonso, J.P, Jiang, H, Andres-Campos, S, Escobedo-Gonzalez, F.C, Titaux-Delgado, G.A, Ubarretxena-Belandia, I, Mompean, M.Show

Nat Commun 16 9607 9607 (2025)

PMID: 41168207 DOI: 10.1038/s41467-025-64621-6

Primary Citation of related structures

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