ISDA: 8YFO

Deposition Date 2024-02-25

Release Date 2025-09-03

Last Version Date 2025-09-03

Entry Detail

PDB ID:

8YFO

Keywords:

MEMBRANE PROTEIN

Title:

A cryo-EM structure of Ac-LA-PTH-PTH1R-Gs complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.71 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:A
Chain Length:361
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:370
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF00400, PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Polymer Type:polypeptide(L)
Molecule:NB35
Chain IDs:D (auth: N)
Chain Length:133
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:Ac-LA-PTH
Chain IDs:E (auth: P)
Chain Length:33
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Parathyroid hormone/parathyro
Gene (Uniprot):PTH1R
Chain IDs:F (auth: R)
Chain Length:476
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q03431 Pfam ID:PF02793, PF00002

Ligand Molecules

Primary Citation

A cryo-EM structure of Ac-LA-PTH-PTH1R-Gs complex

Zhao, L, He, Q, Yuan, Q, Gu, Y, He, X, Shan, H, Xu, H.E.Show

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Primary Citation of related structures

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