ISDA: 8WS3

Deposition Date 2023-10-16

Release Date 2024-10-23

Last Version Date 2024-10-23

Entry Detail

PDB ID:

8WS3

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of SARS-CoV-2 Main Protease (Mpro) with covalent inhibitor 5,8-Dihydroxy-1,4-naphthoquinone

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Chain IDs:A (auth: B), B (auth: A)
Chain Length:306
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTC1 Pfam ID:PF05409 EC:3.4.22.69

Ligand Molecules

DMS

PEG

X7F

Primary Citation

Covalent inhibitors of SARS-CoV-2 main protease

Yang, Y, Wu, D.Show

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Primary Citation of related structures

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