ISDA: 5XTI

Deposition Date 2017-06-19

Release Date 2017-09-13

Last Version Date 2025-09-17

Entry Detail

PDB ID:

5XTI

Keywords:

OXIDOREDUCTASE/ELECTRON TRANSPORT

Title:

Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Bos taurus (Taxon ID: 9913)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

17.40 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX4I1
Chain IDs:WA (auth: 0), YD (auth: B0)
Chain Length:144
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P00423 Pfam ID:PF02936 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX5A
Chain IDs:XA (auth: 1), ZD (auth: B1)
Chain Length:109
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P00426 Pfam ID:PF02284 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX5B
Chain IDs:YA (auth: 2), AE (auth: B2)
Chain Length:98
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P00428 Pfam ID:PF01215 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX6A2
Chain IDs:ZA (auth: 3), BE (auth: B3)
Chain Length:84
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P07471 Pfam ID:PF02046 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX6B1
Chain IDs:AB (auth: 4), CE (auth: B4)
Chain Length:75
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P00429 Pfam ID:PF02297 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX6C
Chain IDs:BB (auth: 5), DE (auth: B5)
Chain Length:73
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P04038 Pfam ID:PF02937 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX7A1
Chain IDs:CB (auth: 6), EE (auth: B6)
Chain Length:56
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P07470 Pfam ID:PF02238 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX7B
Chain IDs:DB (auth: 7), FE (auth: B7)
Chain Length:49
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P13183 Pfam ID:PF05392 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX7C
Chain IDs:EB (auth: 8), GE (auth: B8)
Chain Length:47
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P00430 Pfam ID:PF02935 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX8B
Chain IDs:FB (auth: 9), HE (auth: B9)
Chain Length:43
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P10175 Pfam ID:PF02285 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFV1
Chain IDs:A, CC (auth: BA)
Chain Length:431
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49821 Pfam ID:PF01512, PF22461, PF10589

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRQ
Chain IDs:GB (auth: AA), RB (auth: AN)
Chain Length:81
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O14949 Pfam ID:PF02939

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRFS1
Chain IDs:HB (auth: AB), SB (auth: AO)
Chain Length:57
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P47985 Pfam ID:PF09165, PF02921, PF00355

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRFS1
Chain IDs:IB (auth: AC), TB (auth: AP)
Chain Length:196
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P47985 Pfam ID:PF09165, PF02921, PF00355

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCR10
Chain IDs:JB (auth: AD), UB (auth: AQ)
Chain Length:62
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9UDW1 Pfam ID:PF05365

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRH
Chain IDs:KB (auth: AE), VB (auth: AR)
Chain Length:74
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P07919 Pfam ID:PF02320

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRB
Chain IDs:LB (auth: AF), WB (auth: AS)
Chain Length:106
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P14927 Pfam ID:PF02271 EC:7.1.1.8

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCR11
Chain IDs:MB (auth: AG), XB (auth: AT)
Chain Length:51
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O14957 Pfam ID:PF08997

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c1, heme protein,
Gene (Uniprot):CYC1
Chain IDs:NB (auth: AH), YB (auth: AU)
Chain Length:241
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P08574 Pfam ID:PF02167

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b
Gene (Uniprot):MT-CYB
Chain IDs:OB (auth: AJ), ZB (auth: AV)
Chain Length:378
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P00156 Pfam ID:PF00033, PF00032

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRC2
Chain IDs:PB (auth: AK), AC (auth: AW)
Chain Length:419
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P22695 Pfam ID:PF00675, PF05193

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome b-c1 complex subun
Gene (Uniprot):UQCRC1
Chain IDs:QB (auth: AL), BC (auth: AY)
Chain Length:446
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P31930 Pfam ID:PF00675, PF05193

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFS8
Chain IDs:B, DC (auth: BB)
Chain Length:176
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O00217 Pfam ID:PF12838

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFS7
Chain IDs:C, EC (auth: BC)
Chain Length:153
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O75251 Pfam ID:PF01058

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA6
Chain IDs:D (auth: E), FC (auth: BE)
Chain Length:113
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P56556 Pfam ID:PF13233

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA2
Chain IDs:E (auth: F), GC (auth: BF)
Chain Length:47
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O43678 Pfam ID:PF05047

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Acyl carrier protein, mitocho
Gene (Uniprot):NDUFAB1
Chain IDs:F (auth: G), V (auth: X), HC (auth: BG), XC (auth: BX)
Chain Length:85
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:O14561 Pfam ID:PF00550

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA5
Chain IDs:G (auth: H), IC (auth: BH)
Chain Length:112
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q16718 Pfam ID:PF04716

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA7
Chain IDs:H (auth: I), JC (auth: BI)
Chain Length:110
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O95182 Pfam ID:PF07347

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA9
Chain IDs:I (auth: J), KC (auth: BJ)
Chain Length:115
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q16795 Pfam ID:PF01370

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFV3
Chain IDs:J (auth: K), LC (auth: BK)
Chain Length:97
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P56181 Pfam ID:PF15880

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFS4
Chain IDs:K (auth: L), MC (auth: BL)
Chain Length:118
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O43181 Pfam ID:PF04800

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):NDUFS1
Chain IDs:L (auth: M), NC (auth: BM)
Chain Length:687
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28331 Pfam ID:PF13510, PF10588, PF22117, PF22151, PF00384, PF09326

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA12
Chain IDs:M (auth: N), OC (auth: BN)
Chain Length:143
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9UI09 Pfam ID:PF05071

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFV2
Chain IDs:N (auth: O), PC (auth: BO)
Chain Length:212
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P19404 Pfam ID:PF01257

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFS3
Chain IDs:O (auth: P), QC (auth: BP)
Chain Length:208
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O75489 Pfam ID:PF00329

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFS2
Chain IDs:P (auth: Q), RC (auth: BQ)
Chain Length:430
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O75306 Pfam ID:PF00346

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA1
Chain IDs:Q (auth: S), SC (auth: BS)
Chain Length:70
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O15239 Pfam ID:PF15879

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFS6
Chain IDs:R (auth: T), TC (auth: BT)
Chain Length:95
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O75380 Pfam ID:PF10276

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA3
Chain IDs:S (auth: U), UC (auth: BU)
Chain Length:83
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O95167 Pfam ID:PF14987

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA11
Chain IDs:T (auth: V), VC (auth: BV)
Chain Length:122
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q86Y39

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA13
Chain IDs:U (auth: W), WC (auth: BW)
Chain Length:320
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9P0J0 Pfam ID:PF06212

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB2
Chain IDs:W (auth: Y), YC (auth: BY)
Chain Length:59
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O95178 Pfam ID:PF14813

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB3
Chain IDs:X (auth: Z), ZC (auth: BZ)
Chain Length:261
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O43676 Pfam ID:PF08122

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB5
Chain IDs:Y (auth: a), AD (auth: Ba)
Chain Length:431
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O43674 Pfam ID:PF09781

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB6
Chain IDs:Z (auth: b), BD (auth: Bb)
Chain Length:176
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O95139 Pfam ID:PF09782

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB8
Chain IDs:AA (auth: c), CD (auth: Bc)
Chain Length:153
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O95169 Pfam ID:PF05821

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB10
Chain IDs:BA (auth: d), DD (auth: Bd)
Chain Length:171
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O96000 Pfam ID:PF10249

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB11
Chain IDs:CA (auth: e), ED (auth: Be)
Chain Length:113
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9NX14 Pfam ID:PF10183

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFC1
Chain IDs:DA (auth: f), FD (auth: Bf)
Chain Length:47
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O43677 Pfam ID:PF15088

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFC2
Chain IDs:EA (auth: g), GD (auth: Bg)
Chain Length:85
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O95298 Pfam ID:PF06374

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFS5
Chain IDs:FA (auth: h), HD (auth: Bh)
Chain Length:112
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O43920 Pfam ID:PF10200

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Chain IDs:GA (auth: i), ID (auth: Bi)
Chain Length:110
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P03891 Pfam ID:PF00361, PF06444

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):NADH3
Chain IDs:HA (auth: j), JD (auth: Bj)
Chain Length:115
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:B9EE38 Pfam ID:PF00507

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):ND4L
Chain IDs:IA (auth: k), KD (auth: Bk)
Chain Length:97
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:V9JN72 Pfam ID:PF00420

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Chain IDs:JA (auth: l), LD (auth: Bl)
Chain Length:118
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P03915 Pfam ID:PF00662, PF00361, PF06455

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):ND6
Chain IDs:KA (auth: m), MD (auth: Bm)
Chain Length:687
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q8HAX7 Pfam ID:PF00499

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB1
Chain IDs:LA (auth: n), ND (auth: Bn)
Chain Length:143
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O75438 Pfam ID:PF08040

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB4
Chain IDs:MA (auth: o), OD (auth: Bo)
Chain Length:212
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O95168 Pfam ID:PF07225

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB9
Chain IDs:NA (auth: p), PD (auth: Bp)
Chain Length:208
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9Y6M9 Pfam ID:PF05347

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Chain IDs:OA (auth: r), QD (auth: Br)
Chain Length:459
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P03905 Pfam ID:PF01059, PF00361

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):ND1
Chain IDs:PA (auth: s), RD (auth: Bs)
Chain Length:70
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:H9PGF0 Pfam ID:PF00146

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA8
Chain IDs:QA (auth: u), SD (auth: Bu)
Chain Length:83
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P51970 Pfam ID:PF06747

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFB7
Chain IDs:RA (auth: v), TD (auth: Bv)
Chain Length:122
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P17568 Pfam ID:PF05676

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):NDUFA10
Chain IDs:SA (auth: w), UD (auth: Bw)
Chain Length:320
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O95299 Pfam ID:PF01712

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):MT-CO1
Chain IDs:TA (auth: x), VD (auth: Bx)
Chain Length:514
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P00396 Pfam ID:PF00115 EC:7.1.1.9

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):MT-CO2
Chain IDs:UA (auth: y), WD (auth: By)
Chain Length:59
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P68530 Pfam ID:PF02790, PF00116

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):MT-CO3
Chain IDs:VA (auth: z), XD (auth: Bz)
Chain Length:261
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P00415 Pfam ID:PF00510 EC:7.1.1.9

Ligand Molecules

8Q1

CDL

FES

FMN

HEA

HEC

HEM

NDP

PEE

PLX

SF4

Primary Citation

Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.

Guo, R, Zong, S, Wu, M, Gu, J, Yang, M.Show

Cell 170 1247 1257.e12 (2017)

PMID: 28844695 DOI: 10.1016/j.cell.2017.07.050

Abstact

The respiratory megacomplex represents the highest-order assembly of respiratory chain complexes, and it allows mitochondria to respond to energy-requiring conditions. To understand its architecture, we examined the human respiratory chain megacomplex-I2III2IV2 (MCI2III2IV2) with 140 subunits and a subset of associated cofactors using cryo-electron microscopy. The MCI2III2IV2 forms a circular structure with the dimeric CIII located in the center, where it is surrounded by two copies each of CI and CIV. Two cytochrome c (Cyt.c) molecules are positioned to accept electrons on the surface of the c1 state CIII dimer. Analyses indicate that CII could insert into the gaps between CI and CIV to form a closed ring, which we termed the electron transport chain supercomplex. The structure not only reveals the precise assignment of individual subunits of human CI and CIII, but also enables future in-depth analysis of the electron transport chain as a whole.

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