ISDA: 10EV

Deposition Date 2026-01-15

Release Date 2026-03-25

Last Version Date 2026-04-08

Entry Detail

PDB ID:

10EV

Keywords:

SIGNALING PROTEIN/Immune System

Title:

OX1-Matured in complex with GluN1-GluN2B, full refinement

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Isoform 4 of Glutamate recept
Chain IDs:A, C
Chain Length:817
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Glutamate receptor
Chain IDs:B, D
Chain Length:787
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Heavy chain
Chain IDs:E (auth: F), G (auth: H)
Chain Length:119
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Light chain
Chain IDs:F (auth: G), H (auth: I)
Chain Length:113
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity.

Kleeman, S.O, Michalski, K, Zhao, X, Steigerwald, R, Ferrer, M, Levett, L, Ertel, E, Schultz, A, Simorowski, N, Moody, P, Wee, T.L, Valente, C, Fox, S, Makuch, M, Thomsen, S, Harrison, R, Regan, C, Preall, J, Gao, Q, Thomas, D, Habel, J, Rubino, R, Irani, S, Furukawa, H, Janowitz, T.Show

Nature ? ? ? (2026)

PMID: 41882353 DOI: 10.1038/s41586-026-10278-0

Primary Citation of related structures

Feedback Form