Search Count: 31
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Co-Crystal Structure Of Phosphorylated Erk2 In Complex With Erk1/2 Inhibitor #16
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2024-03-27 Classification: SIGNALING PROTEIN,TRANSFERASE/INHIBITOR Ligands: WAL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-03-27
Ligands: WAL
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Co-Crystal Structure Of Phosphorylated Erk2 In Complex With Erk1/2 Inhibitor #8
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2024-03-27 Classification: SIGNALING PROTEIN,TRANSFERASE/INHIBITOR Ligands: W8U |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-03-27
Ligands: W8U
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Kras G12D In Complex With Mrtx-1133
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.30 Å Release Date: 2021-12-22 Classification: Hydrolase/Hydrolase Inhibitor Ligands: GDP, 6IC, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 6IC, MG
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Crystal Structure Of Kras G12D With Compound 15 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.27 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7L8 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7L8
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Crystal Structure Of Kras G12D With Compound 25 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2R,4R,7As)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.59 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7NL, GOL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7NL, GOL, EDO
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Crystal Structure Of Kras G12D With Compound 24 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S,4S,7Ar)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7NZ, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7NZ, MG
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Kras G12D In Complex With Compound 5B (7-(8-Chloronaphthalen-1-Yl)-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}-4-(Piperazin-1-Yl)Pyrido[4,3-D]Pyrimidine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7IZ, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7IZ, GOL
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Crystal Structure Of Kras G12D With Compound 36 (4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-7-(8-Ethynyl-7-Fluoronaphthalen-1-Yl)-8-Fluoro-2-{[(4S,7As)-Tetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidine) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.29 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7OE, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7OE, MG
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Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.27 Å Release Date: 2020-04-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, M1R |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22
Ligands: GDP, MG, M1R
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Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.03 Å Release Date: 2020-04-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, QH4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22
Ligands: GDP, MG, QH4
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Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.94 Å Release Date: 2020-04-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, M1X |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22
Ligands: GDP, MG, M1X
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Phosphorylated Erk2 With Amp-Pnp
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.90 Å Release Date: 2019-07-31 Classification: TRANSFERASE Ligands: ANP, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-07-31
Ligands: ANP, MG
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Phosphorylated Erk2 With Gdc-0994
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2019-07-31 Classification: TRANSFERASE Ligands: 6QB |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-07-31
Ligands: 6QB
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Phosphorylated Erk2 With Sch-Cpd336
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.00 Å Release Date: 2019-07-31 Classification: TRANSFERASE Ligands: N0V |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-07-31
Ligands: N0V
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Phosphorylated Erk2 With Vertex-11E
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION Resolution:2.54 Å Release Date: 2019-07-31 Classification: TRANSFERASE Ligands: 390 |
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION
Release Date: 2019-07-31
Ligands: 390
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Tetrahydropyridopyrimidines As Covalent Inhibitors Of Kras-G12C
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2018-12-12 Classification: ONCOPROTEIN Ligands: GDP, MG, K9M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2018-12-12
Ligands: GDP, MG, K9M
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Tetrahydropyridopyrimidines As Covalent Inhibitors Of Kras-G12C
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.72 Å Release Date: 2018-12-12 Classification: ONCOPROTEIN Ligands: GDP, MG, K9J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2018-12-12
Ligands: GDP, MG, K9J
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Synthesis, Characterization And Pk/Pd Studies Of A Series Of Spirocyclic Pyranochromene Bace1 Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-05-14 Classification: Hydrolase/Hydrolase inhibitor Ligands: NI, 2X4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-14
Ligands: NI, 2X4
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Synthesis, Characterization And Pk/Pd Studies Of A Series Of Spirocyclic Pyranochromene Bace1 Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-05-14 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 2X5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-14
Ligands: NI, 2X5
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Akt1 With Amp-Pnp
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2012-05-23 Classification: TRANSFERASE Ligands: ANP, MN |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-05-23
Ligands: ANP, MN