Search Count: 18
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Aminomethyl-Derived Beta Secretase (Bace1) Inhibitors: Engaging Gly230 Without An Anilide Functionality
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2017-01-11 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: P6U, IOD, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-01-11
Ligands: P6U, IOD, EDO
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Aminomethyl-Derived Beta Secretase (Bace1) Inhibitors: Engaging Gly230 Without An Anilide Functionality
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.96 Å Release Date: 2017-01-11 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: 74B, IOD, NA, GOL, DMS, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-01-11
Ligands: 74B, IOD, NA, GOL, DMS, CL
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Structure Of Cytochrome P450 2D6 (Cyp2D6) Bace1 Inhibitor Complex
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.71 Å Release Date: 2017-01-11 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor Ligands: HEM, ZN, P6U |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-01-11
Ligands: HEM, ZN, P6U
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Structure Of Cytochrome P450 2D6 (Cyp2D6) Bace1 Inhibitor Complex
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.75 Å Release Date: 2017-01-11 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor Ligands: HEM, ZN, P6M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-01-11
Ligands: HEM, ZN, P6M
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Human Cytochrome P450 2D6 Bace1 Inhibitor 5 Complex
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2015-05-20 Classification: OXIDOREDUCTASE Ligands: HEM, SI5, ZN |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-05-20
Ligands: HEM, SI5, ZN
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Human Cytochrome P450 2D6 Bace1 Inhibitor 6 Complex
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2015-05-20 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: HEM, SI6, ZN, GOL, NA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-05-20
Ligands: HEM, SI6, ZN, GOL, NA
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Crystal Structure Of Bace1 With A Pyrazole-Substituted Tetrahydropyran Thioamidine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.86 Å Release Date: 2015-04-01 Classification: hydrolase/hydrolase inhibitor Ligands: SI5, IOD, GOL, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-04-01
Ligands: SI5, IOD, GOL, DMS
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Crystal Structure Of Human Bace-1 Bound To Compound 24B
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.98 Å Release Date: 2015-03-04 Classification: Hydrolase/hydrolase inhibitor Ligands: 3VO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-03-04
Ligands: 3VO
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Crystal Structure Of Human Bace-1 Bound To Compound 36
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2015-03-04 Classification: Hydrolase/hydrolase inhibitor Ligands: 3VP, IOD, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-03-04
Ligands: 3VP, IOD, DMS
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Crystal Structure Of Human Bace-1 Bound To Compound 6
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.55 Å Release Date: 2015-03-04 Classification: Hydrolase/Hydrolase inhibitor Ligands: 3WP, IOD, NA, GOL, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-03-04
Ligands: 3WP, IOD, NA, GOL, DMS
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Bace1 In Complex With The Aminohydantoin Compound 102
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2011-08-31 Classification: hydrolase/hydrolase inhibitor Ligands: ZOO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-08-31
Ligands: ZOO
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Human Bace-1 In Complex With N-((1S,2R)-1-Benzyl-2-Hydroxy-3-((1,1,5- Trimethylhexyl)Amino)Propyl)-3-(Ethylamino)-5-(2-Oxopyrrolidin-1-Yl) Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2008-01-29 Classification: HYDROLASE Ligands: VG0 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-01-29
Ligands: VG0
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Human Bace-1 In Complex With 3-(1,1-Dioxidotetrahydro-2H-1,2-Thiazin- 2-Yl)-5-(Ethylamino)-N-((1S,2R)-2-Hydroxy-1-(Phenylmethyl)-3-(1,2,3,4- Tetrahydro-1-Naphthalenylamino)Propyl)Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2008-01-29 Classification: HYDROLASE Ligands: C44 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-01-29
Ligands: C44
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Human Bace-1 In Complex With N-((1S,2R)-3-(((1S)-2-(Cyclohexylamino)- 1-Methyl-2-Oxoethyl)Amino)-2-Hydroxy-1-(Phenylmethyl)Propyl)-3-(Pentylsulfonyl)Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.82 Å Release Date: 2008-01-29 Classification: HYDROLASE Ligands: VG3 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-01-29
Ligands: VG3
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Human Bace-1 In Complex With N-((1S,2R)-3-(((1S)-2-(Cyclohexylamino)- 1-Methyl-2-Oxoethyl)Amino)-2-Hydroxy-1-(Phenylmethyl)Propyl)-3-(2-Oxo- 1-Pyrrolidinyl)-5-(Propyloxy)Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2008-01-29 Classification: HYDROLASE Ligands: VG4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-01-29
Ligands: VG4
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Human Bace-1 In Complex With N-((1S,2R)-3-(((1S)-2-(Cyclohexylamino)- 1-Methyl-2-Oxoethyl)Amino)-2-Hydroxy-1-(Phenylmethyl)Propyl)-3-(Ethylamino)-5-(2-Oxo-1-Pyrrolidinyl)Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2008-01-29 Classification: HYDROLASE Ligands: VG5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-01-29
Ligands: VG5
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Human Bace-1 In Complex With 3-(Ethylamino)-N-((1S,2R)-2-Hydroxy-1-(Phenylmethyl)-3-(((3-(Trifluoromethyl)Phenyl)Methyl)Amino)Propyl)-5-(2-Oxo-1-Pyrrolidinyl)Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2008-01-29 Classification: HYDROLASE Ligands: VG6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-01-29
Ligands: VG6
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Human Bace-1 In Complex With N-((1S,2R)-3-(Cyclohexylamino)-2-Hydroxy- 1-(Phenylmethyl)Propyl)-3-(Ethylamino)-5-(2-Oxo-1-Pyrrolidinyl) Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2008-01-29 Classification: HYDROLASE Ligands: VG7 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-01-29
Ligands: VG7