Search Count: 21
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Cdk2 In Complex With Cpd14 (5-Fluoro-4-(4-Methyl-5,6,7,8-Tetrahydro-4H-Pyrazolo[1,5-A]Azepin-3-Yl)-N-(5-(4-Methylpiperazin-1-Yl)Pyridin-2-Yl)Pyrimidin-2-Amine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2020-07-29 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: N14 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-07-29
Ligands: N14
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Cdk6 In Complex With Cpd13 (R)-5-Fluoro-4-(4-Methyl-5,6,7,8-Tetrahydro-4H-Pyrazolo[1,5-A]Azepin-3-Yl)-N-(5-(4-Methylpiperazin-1-Yl)Pyridin-2-Yl)Pyrimidin-2-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.71 Å Release Date: 2020-07-29 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: N1A |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-07-29
Ligands: N1A
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Cdk6 In Complex With Cpd24 N-(5-(6-Ethyl-2,6-Diazaspiro[3.3]Heptan-2-Yl)Pyridin-2-Yl)-5-Fluoro-4-(4-Methyl-5,6,7,8-Tetrahydro-4H-Pyrazolo[1,5-A]Azepin-3-Yl)Pyrimidin-2-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.98 Å Release Date: 2020-07-29 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: N1J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-07-29
Ligands: N1J
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P110Alpha/P85Alpha With Compound 5
Organism: Homo sapiens, Bos taurus
Method: X-RAY DIFFRACTION Resolution:3.00 Å Release Date: 2016-01-27 Classification: Transferase/Transferase Inhibitor Ligands: 5H2 |
Organism: Homo sapiens, Bos taurus
Method: X-RAY DIFFRACTION
Release Date: 2016-01-27
Ligands: 5H2
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P110Alpha With Gdc-0326
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.25 Å Release Date: 2016-01-27 Classification: Transferase/Inhibitor Ligands: 5H5, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-27
Ligands: 5H5, EDO
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P110Delta/P85Alpha With Gdc-0326
Organism: Homo sapiens, Bos taurus
Method: X-RAY DIFFRACTION Resolution:2.64 Å Release Date: 2016-01-27 Classification: Transferase/Inhibitor Ligands: 5H5 |
Organism: Homo sapiens, Bos taurus
Method: X-RAY DIFFRACTION
Release Date: 2016-01-27
Ligands: 5H5
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Discovery Of Thiazolobenzoxepin Pi3-Kinase Inhibitors That Spare The Pi3-Kinase Beta Isoform
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.90 Å Release Date: 2013-08-28 Classification: Transferase/Transferase Inhibitor Ligands: 1JV |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-08-28
Ligands: 1JV
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Compound 21 (1-Alkyl-Substituted 1,2,4-Triazoles)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.78 Å Release Date: 2013-01-09 Classification: Transferase/Transferase Inhibitor Ligands: 17V |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-01-09
Ligands: 17V
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Rational Design Of Pi3K-Alpha Inhibitors That Exhibit Selectivity Over The Pi3K-Beta Isoform
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2011-11-16 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 3T8 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-11-16
Ligands: 3T8
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Discovery Of Gdc-0980: A Potent, Selective, And Orally Available Class I Phosphatidylinositol 3-Kinase (Pi3K)/Mammalian Target Of Rapamycin (Mtor) Kinase Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.79 Å Release Date: 2011-11-02 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 980 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-11-02
Ligands: 980
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Structure-Based Design Of Thienobenzoxepin Inhibitors Of Pi3- Kinase
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2011-08-03 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: FAV |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-08-03
Ligands: FAV
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Structure-Based Design Of Thienobenzoxepin Inhibitors Of Pi3-Kinase
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.90 Å Release Date: 2011-08-03 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: FAZ |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-08-03
Ligands: FAZ
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Non-Oxime Pyrazole Based Inhibitors Of B-Raf Kinase
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.60 Å Release Date: 2011-05-18 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: SM7 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-05-18
Ligands: SM7
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Structure-Based Optimization Of Pyrazolo -Pyrimidine And -Pyridine Inhibitors Of Pi3-Kinase
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.75 Å Release Date: 2010-12-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: NZS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-12-29
Ligands: NZS
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Structure-Based Optimization Of Pyrazolo -Pyrimidine And -Pyridine Inhibitors Of Pi3-Kinase
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2010-12-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: NZU |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-12-29
Ligands: NZU
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Crystal Structures Of Pan-Pi3-Kinase And Dual Pan-Pi3-Kinase/Mtor Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.00 Å Release Date: 2010-02-16 Classification: TRANSFERASE Ligands: JZW |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-02-16
Ligands: JZW
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Discovery Of (Thienopyrimidin-2-Yl)Aminopyrimidines As Potent, Selective, And Orally Available Pan-Pi3-Kinase And Dual Pan-Pi3-Kinase/Mtor Inhibitors For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.90 Å Release Date: 2010-02-16 Classification: TRANSFERASE Ligands: JZX |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-02-16
Ligands: JZX
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Discovery Of (Thienopyrimidin-2-Yl)Aminopyrimidines As Potent, Selective, And Orally Available Pan-Pi3-Kinase And Dual Pan-Pi3-Kinase/Mtor Inhibitors For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.00 Å Release Date: 2010-02-16 Classification: TRANSFERASE Ligands: JZY |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-02-16
Ligands: JZY
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Pyrazole-Based Inhibitors Of B-Raf Kinase
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2008-08-19 Classification: TRANSFERASE Ligands: SM5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-08-19
Ligands: SM5
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Structure Of Pi3K Gamma In Complex With Gdc0941
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2008-06-17 Classification: TRANSFERASE Ligands: GD9 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-06-17
Ligands: GD9