Search Count: 20
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Crystal Structure Of Cyp46A1 With [(1R,5S)-3-Oxa-8-Azabicyclo[3.2.1]Octan-8-Yl][(4R,8M)-8-(1,3-Oxazol-5-Yl)-6-(Trifluoromethyl)Imidazo[1,2-A]Pyridin-3-Yl]Methanone (Compound 3K)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.67 Å Release Date: 2025-07-02 Classification: HYDROLASE/INHIBITOR Ligands: HEM, A1BZE |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-07-02
Ligands: HEM, A1BZE
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Crystal Structure Of Cyp46A1 With (Morpholin-4-Yl)[(4R,8M)-8-(1,3-Oxazol-5-Yl)-6-(Trifluoromethyl)Imidazo[1,2-A]Pyridin-3-Yl]Methanone (Compound 2H)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2025-07-02 Classification: HYDROLASE/INHIBITOR Ligands: HEM, A1BZD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-07-02
Ligands: HEM, A1BZD
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Crystal Structure Of Cyp46A1 With Cyclopropyl[(4M)-4-(1,3-Oxazol-5-Yl)-6-(Trifluoromethyl)-1H-Indol-1-Yl]Methanone (Compound 2B)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2025-07-02 Classification: HYDROLASE/INHIBITOR Ligands: HEM, A1BZC, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-07-02
Ligands: HEM, A1BZC, EDO
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Crystal Structure Of Cyp46A1 With 3-Chloro-N-[(3M)-3-(1,3-Oxazol-5-Yl)Phenyl]-N-(Propan-2-Yl)Benzene-1-Sulfonamide (Compound 2)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.29 Å Release Date: 2025-04-23 Classification: HYDROLASE/INHIBITOR Ligands: HEM, A1BZB, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-04-23
Ligands: HEM, A1BZB, EDO
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Crystal Structure Of Cyp46A1 With 3-Chloro-N-[(3M)-3-(1,3-Oxazol-5-Yl)-5-(Trifluoromethyl)Phenyl]Benzamide (Compound 3F)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2025-04-23 Classification: HYDROLASE/INHIBITOR Ligands: HEM, A1BZA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-04-23
Ligands: HEM, A1BZA
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Crystal Structure Of Cyp46A1 With N-[6-(1,3-Oxazol-5-Yl)-4-(Trifluoromethyl)Pyridin-2-Yl]Cyclopropanecarboxamide (Compound 4L)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2025-04-23 Classification: HYDROLASE/INHIBITOR Ligands: HEM, A1BY9, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-04-23
Ligands: HEM, A1BY9, EDO
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Crystal Structure Of Human Prkaca Complexed With Ds01080522
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2022-09-28 Classification: TRANSFERASE Ligands: I5G, ZN |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-09-28
Ligands: I5G, ZN
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Co-Complex Cyp46A1 With Compound 3F
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.40 Å Release Date: 2022-07-27 Classification: OXIDOREDUCTASE Ligands: HEM, 0I1, EDO, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-07-27
Ligands: HEM, 0I1, EDO, GOL
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Co-Complex Cyp46A1 With 0420 (Compound 6)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.63 Å Release Date: 2022-02-23 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: HEM, EDO, 04Y, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-02-23
Ligands: HEM, EDO, 04Y, GOL
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Co-Complex Cyp46A1 With 0431 (Compound 17)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2022-02-23 Classification: HYDROLASE Ligands: HEM, 05D |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-02-23
Ligands: HEM, 05D
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Co-Complex Cyp46A1 With 7742 (Soticlestat/Tak-935))
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2021-08-25 Classification: HYDROLASE Ligands: HEM, YBS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-08-25
Ligands: HEM, YBS
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Co-Complex Cyp46A1 With 8114 (3F)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.15 Å Release Date: 2021-08-25 Classification: HYDROLASE Ligands: HEM, YCJ |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-08-25
Ligands: HEM, YCJ
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Co-Complex Cyp46A1 With 9129 (1B)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2021-08-25 Classification: HYDROLASE Ligands: HEM, YCG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-08-25
Ligands: HEM, YCG
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Identification Of Novel, Potent And Selective Gcn2 Inhibitors As First-In-Class Anti-Tumor Agents
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.61 Å Release Date: 2019-10-09 Classification: transferase/transferase inhibitor Ligands: KAV |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-10-09
Ligands: KAV
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Identification Of Novel, Potent And Selective Gcn2 Inhibitors As First-In-Class Anti-Tumor Agents
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.01 Å Release Date: 2019-10-09 Classification: transferase/transferase inhibitor Ligands: KA4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-10-09
Ligands: KA4
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Identification Of Novel, Potent And Selective Gcn2 Inhibitors As First-In-Class Anti-Tumor Agents
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2019-10-09 Classification: transferase/transferase inhibitor Ligands: KA7 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-10-09
Ligands: KA7
 |
Halk In Complex With Compound 7 N-((1S)-1-(5-Fluoropyridin-2-Yl)Ethyl)-1-(5-Methyl-1H-Pyrazol-3-Yl)-3-(Oxetan-3-Ylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridin-6-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2019-05-01 Classification: PROTEIN BINDING Ligands: HKJ |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-05-01
Ligands: HKJ
 |
Halk In Complex With Compound 9 (6-(((1S)-1-(5-Fluoropyridin-2-Yl)Ethyl)Amino)-1-(3-Methyl-1H-Pyrazol-5-Yl)-1H-Pyrrolo[2,3-B]Pyridin-3-Yl)(Morpholin-4-Yl)Methanone
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.46 Å Release Date: 2019-05-01 Classification: TRANSFERASE/INHIBITOR Ligands: J3Y |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-05-01
Ligands: J3Y
 |
Halk In Complex With Compound 1 (S)-N-(1-(2,4-Difluorophenyl)Ethyl)-3-(3-Methyl-1H-Pyrazol-5-Yl)Imidazo[1,2-B]Pyridazin-6-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2019-05-01 Classification: TRANSFERASE/INHIBITOR Ligands: J4M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-05-01
Ligands: J4M
 |
Discovery Of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(Trifluoromethoxy)Phenyl]-2-Methoxyethyl}-7-Methoxy-2-Oxo-2,3-Dihydropyrido[2,3-B]Pyrazine-4(1H)-Carboxamide (Tak-915), A Highly Potent, Selective, And Brain-Penetrating Phosphodiesterase 2A Inhibitor For The Treatment Of Cognitive Disorders
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.86 Å Release Date: 2017-12-27 Classification: Hydrolase/Hydrolase Inhibitor Ligands: ZN, MG, 9GA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-12-27
Ligands: ZN, MG, 9GA