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Aldh1A1 N121S In Complex With 6-{[(3-Fluorophenyl)Methyl]Sulfanyl}-2-(Oxetan-3-Yl)-5-Phenyl-2,5-Dihydro-4H-Pyrazolo[3,4-D]Pyrimidin-4-One (Compound 13G)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2019-05-01 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: YB, A5Y, NAI, CL |
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Co-Crystal Structure Of The Hsp90 Atp Binding Domain In Complex With 4-(2,4-Dichloro-5-Methoxyphenyl)-6-Methylpyrimidin-2-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2011-06-08 Classification: CHAPERONE Ligands: 3RP, PO4 |
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Co-Crystal Structure Of The Hsp90 Atp Binding Domain In Complex With 4-(2,4-Dichloro-5-Methoxyphenyl)-2-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine-5- Carbonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2011-06-08 Classification: CHAPERONE Ligands: 3RQ, PO4 |
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Co-Crystal Structure Of The Hsp90 Atp Binding Domain In Complex With 4-(2,4-Dichloro-5-Methoxyphenyl)-2,6-Dimethyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2011-06-08 Classification: CHAPERONE Ligands: 3RR, PO4 |
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Optimization Of Potent, Selective, And Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors Of Heat Shock Protein 90. Identification Of Development Candidate 2-Amino-4-{4-Chloro-2-[2-(4-Fluoro-1H-Pyrazol-1-Yl)Ethoxy]-6-Methylphenyl}-N-(2,2-Difluoropropyl)-5,7-Dihydro-6H-Pyrrolo[3,4-D]Pyrimidine-6-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2011-04-27 Classification: Chaperone/Chaperone inhibitor Ligands: WOE |
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Optimization Of Potent, Selective, And Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors Of Heat Shock Protein 90. Identification Of Development Candidate 2-Amino-4-{4-Chloro-2-[2-(4-Fluoro-1H-Pyrazol-1-Yl)Ethoxy]-6-Methylphenyl}-N-(2,2-Difluoropropyl)-5,7-Dihydro-6H-Pyrrolo[3,4-D]Pyrimidine-6-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2011-04-27 Classification: Chaperone/Chaperone inhibitor Ligands: FU5 |
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Optimization Of Potent, Selective, And Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors Of Heat Shock Protein 90. Identification Of Development Candidate 2-Amino-4-{4-Chloro-2-[2-(4-Fluoro-1H-Pyrazol-1-Yl)Ethoxy]-6-Methylphenyl}-N-(2,2-Difluoropropyl)-5,7-Dihydro-6H-Pyrrolo[3,4-D]Pyrimidine-6-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.65 Å Release Date: 2011-04-27 Classification: Chaperone/Chaperone inhibitor Ligands: FU3 |
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Optimization Of Potent, Selective, And Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors Of Heat Shock Protein 90. Identification Of Development Candidate 2-Amino-4-{4-Chloro-2-[2-(4-Fluoro-1H-Pyrazol-1-Yl)Ethoxy]-6-Methylphenyl}-N-(2,2-Difluoropropyl)-5,7-Dihydro-6H-Pyrrolo[3,4-D]Pyrimidine-6-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2011-04-27 Classification: Chaperone/Chaperone inhibitor Ligands: FU7, PO4 |
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Crystal Structure Of The 6-Hyroxymethyl-7,8-Dihydropterin Pyrophosphokinase Dihydropteroate Synthase Bifunctional Enzyme From Francisella Tularensis
Organism: Francisella tularensis subsp. holarctica
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2010-12-22 Classification: TRANSFERASE Ligands: MG |
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Crystal Structure Of The 6-Hyroxymethyl-7,8-Dihydropterin Pyrophosphokinase Dihydropteroate Synthase Bifunctional Enzyme From Francisella Tularensis
Organism: Francisella tularensis subsp. holarctica
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2010-12-22 Classification: TRANSFERASE Ligands: MG, B57 |
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Crystal Structure Of The 6-Hyroxymethyl-7,8-Dihydropterin Pyrophosphokinase Dihydropteroate Synthase Bifunctional Enzyme From Francisella Tularensis
Organism: Francisella tularensis subsp. holarctica
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2010-12-22 Classification: TRANSFERASE Ligands: PH2, APC, MG |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2010-10-06 Classification: HYDROLASE Ligands: ZN, CA, 3KR |
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Hsp90 N-Terminal Domain In Complex With 4-Chloro-6-{[(2R)-2-(2-Methylphenyl)Pyrrolidin-1-Yl]Carbonyl}Benzene-1,3-Diol
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2010-02-09 Classification: CHAPERONE Ligands: 4CD, DMS |
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Hsp90 N-Terminal Domain In Complex With (1R)-2-(5-Chloro-2,4-Dihydroxybenzoyl)-N-Ethylisoindoline-1-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2010-02-09 Classification: CHAPERONE Ligands: 1RC, PO4 |
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Hsp90 N-Terminal Domain In Complex With 4-(1,3-Dihydro-2H-Isoindol-2-Ylcarbonyl)Benzene-1,3-Diol
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2010-02-09 Classification: CHAPERONE Ligands: PFT |
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Hsp90 N-Terminal Domain In Complex With 1-{4-[(2R)-1-(5-Chloro-2,4-Dihydroxybenzoyl)Pyrrolidin-2-Yl]Benzyl}-3,3-Difluoropyrrolidinium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2009-09-29 Classification: CHAPERONE Ligands: BD0, PO4 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.55 Å Release Date: 2008-11-25 Classification: CHAPERONE Ligands: PYU, PO4 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2008-11-25 Classification: CHAPERONE Ligands: PY9, PO4 |