Search Count: 45
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Bace-1 In Complex With (7Ar)-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-6-(5-Fluoropyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.65 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 60Y |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: TLA, 60Y
 |
Bace-1 Incomplex With (7Ar)-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-6-(5-Fluoro-4-Methoxypyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 60W |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: TLA, 60W
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Bace-1 Incomplex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(5-Fluoro-4-Methoxy-6-Methylpyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.71 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60V, TLA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60V, TLA
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Bace-1 In Complex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(4-Ethoxy-5-Fluoro-6-Methylpyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60U |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60U
 |
Bace-1 In Complex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(5-Fluoro-4-Methyl-6-(Methylthio)Pyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.49 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 954 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 954
 |
Bace-1 In Complex With (4Ar,7As)-7A-(2,6-Difluorophenyl)-6-(5-Fluoro-4-Methoxy-6-Methylpyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.53 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60T, TLA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60T, TLA
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Bace-1 In Complex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(5-Fluoro-4-Methyl-6-(Methylamino)Pyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.55 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 60S |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: TLA, 60S
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Bace-1 In Complex With (4Ar,7As)-7A-(2,4-Difluorophenyl)-6-(5-Fluoro-4-Methoxy-6-Methylpyrimidin-2-Yl)-2-Imino-3-Methyloctahydro-4H-Pyrrolo[3,4-D]Pyrimidin-4-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.71 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60X |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60X
 |
Renin In Complex With (S)-1-(3-Fluoro-5-(((S)-1-Phenylethyl)Carbamoyl)Benzyl)-4-Isopropyl-4-Methyl-6-Oxotetrahydropyrimidin-2(1H)-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2015-02-25 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: NAG, 43T |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-02-25
Ligands: NAG, 43T
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Renin In Complex With (S)-1-(3-(Benzylcarbamoyl)Benzyl)-4-Isopropyl-4-Methyl-6-Oxotetrahydropyrimidin-2(1H)-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2015-02-18 Classification: Hydrolase/Hydrolase Inhibitor Ligands: NAG, 70X |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-02-18
Ligands: NAG, 70X
 |
Renin In Complex With (4S)-4-Isopropyl-4-Methyl-6-Oxo-1-(3-(2-Oxo-4-Phenylpyrrolidin-1-Yl)Benzyl)Tetrahydropyrimidin-2(1H)-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2015-02-18 Classification: Hydrolase/Hydrolase Inhibitor Ligands: NAG, 70Y |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-02-18
Ligands: NAG, 70Y
 |
Bace-1 In Complex With (R)-4-(2-Cyclohexylethyl)-4-(((R)-1-(2-Cyclopentylacetyl)Pyrrolidin-3-Yl)Methyl)-1-Methyl-5-Oxoimidazolidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2014-11-05 Classification: Hydrolase/Hydrolase Inhibitor Ligands: 3KO, TLA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-11-05
Ligands: 3KO, TLA
 |
Bace-1 In Complex With (R)-4-(2-Cyclohexylethyl)-4-(((1S,3R)-3-(Cyclopentylamino)Cyclohexyl)Methyl)-1-Methyl-5-Oxoimidazolidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2014-11-05 Classification: Hydrolase/Hydrolase inhibitor Ligands: TLA, 3KT |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-11-05
Ligands: TLA, 3KT
 |
Bace-1 In Complex With (R)-4-(2-Cyclohexylethyl)-4-(((1S,3R)-3-(Isonicotinamido)Cyclohexyl)Methyl)-1-Methyl-5-Oxoimidazolidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.71 Å Release Date: 2014-11-05 Classification: Hydrolase/Hydrolase inhibitor Ligands: 3KU, TLA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-11-05
Ligands: 3KU, TLA
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Bace-1 In Complex With (R)-4-(2-Cyclohexylethyl)-1-Methyl-5-Oxo-4-(((1S,3R)-3-(3-Phenylureido)Cyclohexyl)Methyl)Imidazolidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.71 Å Release Date: 2014-11-05 Classification: Hydrolase/Hydrolase inhibitor Ligands: TLA, 779 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-11-05
Ligands: TLA, 779
 |
Bace-1 In Complex With 2-(((1R,3S)-3-(((R)-4-(2-Cyclohexylethyl)-2-Iminio-1-Methyl-5-Oxoimidazolidin-4-Yl)Methyl)Cyclohexyl)Amino)Quinolin-1-Ium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.99 Å Release Date: 2014-11-05 Classification: Hydrolase/Hydrolase inhibitor Ligands: TLA, 3KW |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-11-05
Ligands: TLA, 3KW
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Structure Of Bace Bound To 3-(5-((7Ar)-2-Imino-6-(6-Methoxypyridin-2-Yl)-3-Methyl-4-Oxooctahydro-1H-Pyrrolo[3,4-D]Pyrimidin-7A-Yl)Thiophen-3-Yl)Benzonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2012-11-07 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 10O |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-11-07
Ligands: TLA, 10O
 |
Structure Of Bace Bound To 2-((7Ar)-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-2-Imino-3-Methyl-4-Oxohexahydro-1H-Pyrrolo[3,4-D]Pyrimidin-6(2H)-Yl)Nicotinonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2012-11-07 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 10Q |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-11-07
Ligands: TLA, 10Q
 |
Structure Of Bace Bound To 3-(5-((7Ar)-2-Imino-6-(3-Methoxypyridin-2-Yl)-3-Methyl-4-Oxooctahydro-1H-Pyrrolo[3,4-D]Pyrimidin-7A-Yl)Thiophen-3-Yl)Benzonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.96 Å Release Date: 2012-11-07 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 10V |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-11-07
Ligands: TLA, 10V
 |
Structure Of Bace-1 Bound To (7Ar)-6-Benzoyl-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-3-Methyl-4-Oxohexahydro-1H-Pyrrolo[3,4-D]Pyrimidin-2(3H)-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2012-10-17 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 10J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-10-17
Ligands: 10J