Search Count: 15
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Synthesis Of Novel Nad Dependant Dna Ligase Inhibitors Via Negishi Cross-Coupling: Development Of Sar And Resistance Studies
Organism: Haemophilus influenzae
Method: X-RAY DIFFRACTION Resolution:2.33 Å Release Date: 2015-10-28 Classification: LIGASE Ligands: IA7, IWH |
Organism: Haemophilus influenzae
Method: X-RAY DIFFRACTION
Release Date: 2015-10-28
Ligands: IA7, IWH
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S.Aureus Tmk In Complex With A Potent Inhibitor Compound 18, 2-(3-Chlorophenoxy)-3-Methoxy-4-{[(3S)-3-(5-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Piperidin-1-Yl]Methyl}Benzoic Acid
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:1.67 Å Release Date: 2014-06-11 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 32K |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2014-06-11
Ligands: 32K
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S.Aureus Tmk In Complex With Potent Inhibitor Compound 19, 2-(3-Chlorophenoxy)-3-Fluoro-4-{[(3S)-3-(5-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Piperidin-1-Yl]Methyl}Benzoic Acid
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:1.94 Å Release Date: 2014-06-11 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 31Z |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2014-06-11
Ligands: 31Z
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S.Aureus Tmk In Complex With The Potent Inhibitor Compound 38, 2-(3-Chlorophenoxy)-3-Methoxy-4-{(1R)-1-[(3S)-3-(5-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Piperidin-1-Yl]Propyl}Benzoic Acid
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:1.83 Å Release Date: 2014-06-11 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 32B |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2014-06-11
Ligands: 32B
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Tmk In Complex With Compound 46, 2-(3-Chlorophenoxy)-3-Fluoro-4-{(1R)-3-Methyl-1-[(3S)-3-(5-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Piperidin-1-Yl]Butyl}Benzoic Acid
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2014-06-11 Classification: Transferase/transferase inhibitor Ligands: 32C |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2014-06-11
Ligands: 32C
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S.Aureus Tmk In Complex With Potent Inhibitor Compound 47
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2014-06-11 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 32E |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2014-06-11
Ligands: 32E
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Sulfonylpiperidines As Novel, Antibacterial Inhibitors Of Gram-Positive Thymidylate Kinase (Tmk): Compound 5
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:1.55 Å Release Date: 2012-10-31 Classification: transferase/transferase inhibitor Ligands: T05 |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2012-10-31
Ligands: T05
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Sulfonylpiperidines As Novel, Antibacterial Inhibitors Of Gram-Positive Thymidylate Kinase (Tmk): Compound 11
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2012-10-31 Classification: transferase/transferase inhibitor Ligands: 16T |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2012-10-31
Ligands: 16T
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Thymidylate Kinase (Tmk) From S. Aureus In Complex With Tk-666
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2012-10-24 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0YB |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2012-10-24
Ligands: 0YB
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Crystal Structure Of Thymidylate Kinase From Staphylococcus Aureus Bound To Inhibitor.
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:1.71 Å Release Date: 2012-10-24 Classification: Transferase/Transferase inhibitor Ligands: 0Y5 |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2012-10-24
Ligands: 0Y5
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Discovery Of Selective And Potent Inhibitors Of Gram-Positive Bacterial Thymidylate Kinase (Tmk: Compound 41)
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2012-10-24 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 13Y |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2012-10-24
Ligands: 13Y
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Discovery Of Selective And Potent Inhibitors Of Gram-Positive Bacterial Thymidylate Kinase (Tmk): Compund 16
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2012-10-24 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 14D |
Organism: Staphylococcus aureus subsp. aureus
Method: X-RAY DIFFRACTION
Release Date: 2012-10-24
Ligands: 14D
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S. Aureus Gyrb Atpase Domain In Complex With Small Molecule Inhibitor
Organism: Staphylococcus aureus
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2012-01-11 Classification: ISOMERASE/ISOMERASE INHIBITOR Ligands: 08B, MG |
Organism: Staphylococcus aureus
Method: X-RAY DIFFRACTION
Release Date: 2012-01-11
Ligands: 08B, MG
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S. Aureus Gyrb Atpase Domain In Complex With A Small Molecule Inhibitor
Organism: Staphylococcus aureus
Method: X-RAY DIFFRACTION Resolution:1.64 Å Release Date: 2012-01-11 Classification: ISOMERASE/ISOMERASE INHIBITOR Ligands: 087, MG |
Organism: Staphylococcus aureus
Method: X-RAY DIFFRACTION
Release Date: 2012-01-11
Ligands: 087, MG
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Crystal Structure Of A Topoisomerase Atpase Inhibitor
Organism: Staphylococcus aureus
Method: X-RAY DIFFRACTION Resolution:1.63 Å Release Date: 2011-11-16 Classification: ISOMERASE/ISOMERASE INHIBITOR Ligands: 07N, MG |
Organism: Staphylococcus aureus
Method: X-RAY DIFFRACTION
Release Date: 2011-11-16
Ligands: 07N, MG