Search Count: 13
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Discovery Of A Stable Macrocyclic O-Aminobenzamide Hsp90 Inhibitor Capable Of Significantly Decreasing Tumor Volume In A Mouse Xenograft Model.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.57 Å Release Date: 2011-07-13 Classification: CHAPERONE/CHAPERONE INHIBITOR Ligands: 06T |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-07-13
Ligands: 06T
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Discovery Of A Macrocyclic O-Aminobenzamide Hsp90 Inhibitor With Heterocyclic Tether That Shows Extended Biomarker Activity And In Vivo Efficacy In A Mouse Xenograft Model.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2011-06-08 Classification: CHAPERONE/CHAPERONE INHIBITOR Ligands: 06J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-06-08
Ligands: 06J
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Macrocyclic Lactams As Potent Hsp90 Inhibitors With Excellent Tumor Exposure And Extended Biomarker Activity.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2011-05-11 Classification: CHAPERONE/CHAPERONE INHIBITOR Ligands: 06H |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-05-11
Ligands: 06H
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Design And Sar Of Macrocyclic Hsp90 Inhibitors With Increased Metabolic Stability And Potent Cell-Proliferation Activity
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.57 Å Release Date: 2011-04-06 Classification: CHAPERONE/CHAPERONE INHIBITOR Ligands: 05S, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-04-06
Ligands: 05S, DMS
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The Complex Of Wild-Type B-Raf With Pyrazolo Pyrimidine Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.79 Å Release Date: 2009-11-10 Classification: TRANSFERASE Ligands: 831, PO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2009-11-10
Ligands: 831, PO4
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Crystal Structure Of Tace With Tryptophan Sulfonamide Derivative Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2009-05-19 Classification: HYDROLASE Ligands: 792, ZN |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2009-05-19
Ligands: 792, ZN
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Crystal Structure Of The Catalytic Domain Of Mmp-13 Complexed With Way-344
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2008-04-22 Classification: HYDROLASE Ligands: ZN, CA, 347 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-04-22
Ligands: ZN, CA, 347
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Crystal Structure Of Catalytic Domain Of Tace With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2006-12-05 Classification: HYDROLASE Ligands: ZN, INN, KGY |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2006-12-05
Ligands: ZN, INN, KGY
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Crystal Structure Of The Catalytic Domain Of Mmp-13 Complexed With Way-033
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2006-05-30 Classification: HYDROLASE Ligands: ZN, CA, 033 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2006-05-30
Ligands: ZN, CA, 033
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Crystal Structure Of Catalytic Domain Of Tace With Thiomorpholine Sulfonamide Hydroxamate Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2006-02-07 Classification: HYDROLASE Ligands: ZN, 4NH |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2006-02-07
Ligands: ZN, 4NH
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Crystal Structure Of Catalytic Domain Of Tnf-Alpha Converting Enzyme (Tace) With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.28 Å Release Date: 2005-09-27 Classification: HYDROLASE Ligands: ZN, IH6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2005-09-27
Ligands: ZN, IH6
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Solution Structure Of The Catalytic Fragment Of Human Collagenase-3 (Mmp-13) Complexed With A Hydroxamic Acid Inhibitor
Organism: Homo sapiens
Method: SOLUTION NMR Release Date: 2001-08-15 Classification: HYDROLASE Ligands: ZN, CA, WAY |
Organism: Homo sapiens
Method: SOLUTION NMR
Release Date: 2001-08-15
Ligands: ZN, CA, WAY
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Solution Structure Of The Catalytic Fragment Of Human Collagenase-3 (Mmp-13) Complexed With A Hydroxamic Acid Inhibitor
Organism: Homo sapiens
Method: SOLUTION NMR Release Date: 2001-08-15 Classification: HYDROLASE Ligands: ZN, CA, WAY |
Organism: Homo sapiens
Method: SOLUTION NMR
Release Date: 2001-08-15
Ligands: ZN, CA, WAY