Search Count: 7
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Discovery Of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(Trifluoromethoxy)Phenyl]-2-Methoxyethyl}-7-Methoxy-2-Oxo-2,3-Dihydropyrido[2,3-B]Pyrazine-4(1H)-Carboxamide (Tak-915), A Highly Potent, Selective, And Brain-Penetrating Phosphodiesterase 2A Inhibitor For The Treatment Of Cognitive Disorders
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2017-08-23 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: ZN, MG, 9GJ |
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Crystal Structure Of Human Phosphodiesterase 2A In Complex With 6-Methyl-N-(1-(4-(Trifluoromethoxy)Phenyl)Propyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.16 Å Release Date: 2017-08-16 Classification: HYDROLASE Ligands: MG, ZN, 87R |
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Crystal Structure Of The Catalytic Domain Of Pde10A Complexed With 1-(2-Fluoro-4-(2-Oxo-1,3-Oxazolidin-3-Yl)Phenyl)-5-Methoxy-3-(1-Phenyl-1H-Pyrazol-5-Yl)Pyridazin-4(1H)-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2015-11-11 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: MG, ZN, 4LK |
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Crystal Structure Of The Catalytic Domain Of Pde10A Complexed With Highly Potent And Brain-Penetrant Pde10A Inhibitor With 2-Oxindole Scaffold
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.77 Å Release Date: 2015-11-11 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: MG, ZN, 4LP, 4LK |
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Crystal Structure Of The Catalytic Domain Of Pde10A Complexed With 3-(1-Phenyl-1H-Pyrazol-5-Yl)-1-(3-(Trifluoromethyl)Phenyl)Pyridazin-4(1H)-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2014-11-19 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: MG, ZN, 3KG |
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Crystal Structure Of The Catalytic Domain Of Pde10A Complexed With 5-Methoxy-3-(1-Phenyl-1H-Pyrazol-5-Yl)-1-(3-(Trifluoromethyl)Phenyl)Pyridazin-4(1H)-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.68 Å Release Date: 2014-11-19 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: ZN, MG, 3KB |
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Crystal Structure Of The Catalytic Domain Of Pde10A Complexed With 1-(2-Fluoro-4-(1H-Pyrazol-1-Yl)Phenyl)-5-Methoxy-3-(1-Phenyl-1H-Pyrazol-5-Yl)Pyridazin-4(1H)-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2014-11-19 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: MG, ZN, 3K9 |